Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LHCGR | P22888 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.37 |
| ▸ | MC5R | P33032 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9924215 | 0.91 | SLC6A9 (0.41) | EPHX2GRM4ALDH1A1CYP2D6MC5R | |
| SCHEMBL9924286 | 0.90 | LHCGR (0.39) | RAPGEF3RAPGEF4EPHX2GRM4ALDH1A1 | |
| SCHEMBL9924262 | 0.87 | UBE2M (0.46) | TRPV1MRGPRX4EPHX2ALDH1A1CYP2D6 | |
| SCHEMBL17206620 | 0.87 | GRM4 (0.39) | TRPV1GRM4ALDH1A1LHCGRCYP2D6 | |
| SCHEMBL17206704 | 0.87 | CYP2D6 (0.37) | TRPV1RAPGEF3RAPGEF4EPHX2LHCGR | |
| SCHEMBL9924081 | 0.85 | TRPV1 (0.44) | TRPV1RAPGEF3RAPGEF4GRM4CYP2D6 | |
| SCHEMBL9924438 | 0.85 | TRPV1 (0.44) | TRPV1RAPGEF3RAPGEF4GRM4CYP2D6 | |
| SCHEMBL17206709 | 0.85 | TRPV1 (0.42) | TRPV1MRGPRX4EPHX2ALDH1A1MEN1 | |
| SCHEMBL9924222 | 0.84 | CYP2D6 (0.44) | EPHX2GRM4CYP2D6CRHR1SLC6A9 | |
| SCHEMBL17206624 | 0.84 | CYP2D6 (0.44) | EPHX2GRM4CYP2D6CRHR1SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169199-B2 | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-10-27 | — | — | US | disclosed |
| US-9169199-B2 | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-10-27 | — | — | US | disclosed |
| WO-2012078867-A2 | CYCLOALKYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |