Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923857 | 0.93 | LMNA (0.40) | SMN1; SMN2LMNACHRM1MAPK14EPHX2 | |
| SCHEMBL9923856 | 0.92 | CHRM1 (0.42) | SMN1; SMN2LMNAMAPTCHRM1MAPK14 | |
| SCHEMBL9924063 | 0.91 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNACHRM1MAPK14TSHR | |
| SCHEMBL9924273 | 0.91 | CHRM1 (0.41) | SMN1; SMN2LMNAMAPTCHRM1MAPK14 | |
| SCHEMBL9924067 | 0.90 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAP2RX7CHRM1MAPK14 | |
| SCHEMBL9924275 | 0.90 | THRB (0.45) | SMN1; SMN2MAPTP2RX7CHRM1MAPK14 | |
| SCHEMBL9924066 | 0.88 | CHRM1 (0.41) | SMN1; SMN2LMNAMAPTCHRM1MAPK14 | |
| SCHEMBL9924064 | 0.88 | CHRM1 (0.40) | SMN1; SMN2LMNAP2RX7CHRM1MAPK14 | |
| SCHEMBL9924270 | 0.87 | HPGD (0.40) | SMN1; SMN2LMNAP2RX7CHRM1EPHX2 | |
| SCHEMBL9924424 | 0.87 | TRPV1 (0.45) | SMN1; SMN2LMNAMAPTCHRM1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169199-B2 | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-10-27 | — | — | US | disclosed |
| WO-2012078867-A2 | CYCLOALKYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |