Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9924267 | 0.93 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2CHRM1MAPK14ROCK2 | |
| SCHEMBL9924066 | 0.92 | CHRM1 (0.41) | LMNASMN1; SMN2CHRM1MAPK14HTT | |
| SCHEMBL9923856 | 0.92 | CHRM1 (0.42) | LMNASMN1; SMN2CHRM1POLBMAPK14 | |
| SCHEMBL9924275 | 0.90 | THRB (0.45) | SMN1; SMN2CHRM1POLBMAPK14ROCK2 | |
| SCHEMBL9924063 | 0.88 | SMN1; SMN2 (0.43) | LMNASMN1; SMN2CHRM1MAPK14HTT | |
| SCHEMBL9924273 | 0.88 | CHRM1 (0.41) | LMNASMN1; SMN2CHRM1POLBMAPK14 | |
| SCHEMBL9923859 | 0.88 | CHRM1 (0.41) | LMNASMN1; SMN2CHRM1POLBMAPK14 | |
| SCHEMBL9924429 | 0.87 | NTRK1 (0.43) | DRD2ADRA1DADRA1AADRA1BROCK2 | |
| SCHEMBL9924067 | 0.87 | SMN1; SMN2 (0.43) | LMNASMN1; SMN2CHRM1POLBMAPK14 | |
| SCHEMBL9923858 | 0.87 | ALDH1A1 (0.41) | LMNASMN1; SMN2CHRM1POLBMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169199-B2 | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-10-27 | — | — | US | disclosed |
| WO-2012078867-A2 | CYCLOALKYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |