Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.41 |
| ▸ | HTR5A | P47898 | 8/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12874646 | 0.90 | GRM2 (0.36) | MAPK14HTR5A | |
| SCHEMBL12875043 | 0.89 | HTR5A (0.45) | MAPK14HTR5ASLC9A1 | |
| SCHEMBL9907826 | 0.89 | HTR5A (0.51) | MAPK14HTR5ASLC9A1 | |
| SCHEMBL12874645 | 0.89 | HTR5A (0.38) | MAPK14HTR5ASLC9A1 | |
| SCHEMBL12875077 | 0.85 | HTR5A (0.45) | MAPK14HTR5A | |
| SCHEMBL12874635 | 0.85 | HTR5A (0.41) | MAPK14HTR5A | |
| SCHEMBL15500584 | 0.82 | PTGDR2 (0.35) | HTR5A | |
| SCHEMBL9907850 | 0.81 | HTR5A (0.44) | HTR5ASLC9A1 | |
| SCHEMBL9925362 | 0.80 | HTR5A (0.38) | HTR5A | |
| SCHEMBL12874637 | 0.80 | HTR5A (0.38) | HTR5ASLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463276-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2012-06-13 | — | — | EP | disclosed |
| WO-2011016504-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | アステラス製薬株式会社 (JP) | 2011-02-10 | — | — | WO | disclosed |