Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | USP7 | Q93009 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GUSB | P08236 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31312510 | 0.87 | PTGS1 (0.46) | ALDH1A1KDM4ESMN1; SMN2HSD17B10RAB9A | |
| SCHEMBL15631815 | 0.86 | KDM4E (0.51) | ALDH1A1KDM4ESMN1; SMN2HSD17B10RAB9A | |
| SCHEMBL20765667 | 0.86 | ALDH1A1 (0.51) | ALDH1A1KDM4ESMN1; SMN2HSD17B10RAB9A | |
| SCHEMBL9893290 | 0.85 | USP7 (0.44) | ALDH1A1KDM4ESMN1; SMN2HSD17B10KMT2A | |
| SCHEMBL9924057 | 0.82 | KDM4E (0.74) | ALDH1A1KDM4ESMN1; SMN2HSD17B10RAB9A | |
| SCHEMBL20765235 | 0.81 | KDM4E (0.46) | ALDH1A1KDM4ESMN1; SMN2HSD17B10RAB9A | |
| SCHEMBL20765788 | 0.81 | KDM4E (0.46) | ALDH1A1KDM4ESMN1; SMN2HSD17B10RAB9A | |
| SCHEMBL9893328 | 0.80 | KDM4E (0.54) | ALDH1A1KDM4ESMN1; SMN2HSD17B10RAB9A | |
| SCHEMBL9893235 | 0.77 | USP7 (0.42) | USP7TRPA1MAT2ANOTUM | |
| SCHEMBL15780493 | 0.76 | USP7 (0.43) | ALDH1A1KDM4ESMN1; SMN2HSD17B10USP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149699-A1 | IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149699-A1 | IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS | TRPM8, TRPV1, TRPM2 | ALDH1A1 2230/4885KDM4E 3480/4885SMN1; SMN2 442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.