Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 2/20 | 0.37 |
| ▸ | RARA | P10276 | 1/20 | 0.37 |
| ▸ | RARG | P13631 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14193997 | 0.88 | CNR1 (0.40) | NPC1RAB9ATP53PKMSMN1; SMN2 | |
| SCHEMBL14525987 | 0.87 | MCL1 (0.40) | ESR1ESR2MCL1RARBRARA | |
| SCHEMBL9926841 | 0.85 | ESR1 (0.35) | ESR1ESR2MCL1RARBRARA | |
| SCHEMBL8165614 | 0.84 | ESR1 (0.44) | ESR1ESR2MCL1RARBRARA | |
| SCHEMBL5683972 | 0.82 | ESR1 (0.41) | ESR1ESR2RARBRARARARG | |
| SCHEMBL14525989 | 0.81 | ESR1 (0.42) | ESR1ESR2MCL1RARBRARA | |
| SCHEMBL3153791 | 0.81 | ESR1 (0.39) | ESR1ESR2MCL1RARBRARA | |
| SCHEMBL16210613 | 0.80 | RARB (0.38) | ESR1ESR2MCL1RARBRARA | |
| SCHEMBL5687005 | 0.79 | NPC1 (0.41) | ESR1ESR2MCL1NPC1RAB9A | |
| SCHEMBL17487572 | 0.79 | ESR1 (0.35) | ESR1ESR2MCL1RARBRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8350100-B2 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2013-01-08 | — | — | US | disclosed |
| US-8350100-B2 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2013-01-08 | — | — | US | disclosed |
| US-20120149943-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | MERCK GMBH (DE) | 2012-06-14 | — | — | US | disclosed |
| US-20120149943-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | MERCK GMBH (DE) | 2012-06-14 | — | — | US | disclosed |
| US-8124817-B2 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2012-02-28 | — | — | US | disclosed |
| US-8124817-B2 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2012-02-28 | — | — | US | disclosed |
| EP-2332944-A2 | Process for the preparation of ring compounds | Merck Patent GmbH (DE) | 2011-06-15 | — | — | EP | disclosed |
| US-20110034738-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | PAULUTH DETLEF | 2011-02-10 | — | — | US | disclosed |
| US-20110034738-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | PAULUTH DETLEF | 2011-02-10 | — | — | US | disclosed |
| US-7842845-B2 | Process for the preparation of ring compounds | MERCK GMBH (DE) | 2010-11-30 | — | — | US | disclosed |
| US-7786332-B2 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2010-08-31 | — | — | US | disclosed |
| US-20090318727-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | PAULUTH DETLEF | 2009-12-24 | — | — | US | disclosed |
| US-20090318727-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | PAULUTH DETLEF | 2009-12-24 | — | — | US | disclosed |
| EP-2103589-A1 | Polypenylenes as liquid crystals | Merck Patent GmbH (DE) | 2009-09-23 | — | — | EP | disclosed |
| US-20080319235-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | PAULUTH DETLEF | 2008-12-25 | — | — | US | disclosed |
| US-20080319235-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | PAULUTH DETLEF | 2008-12-25 | — | — | US | disclosed |
| US-7411100-B2 | Process for the preparation of ring compounds | MERCK GMBH (DE) | 2008-08-12 | — | — | US | disclosed |
| US-7411100-B2 | Process for the preparation of ring compounds | MERCK GMBH (DE) | 2008-08-12 | — | — | US | disclosed |
| US-7183447-B2 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2007-02-27 | — | — | US | disclosed |
| US-7183447-B2 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2007-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149943-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | NBAS, HDHD5, DBF4 | ESR1 3804/4885ESR2 3613/4885MCL1 660/4885 |
| US-20080319235-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | NBAS, HDHD5, DBF4 | ESR1 3800/4885ESR2 3636/4885MCL1 680/4885 |
| US-20110034738-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | NBAS, HDHD5, DBF4 | ESR1 3800/4885ESR2 3636/4885MCL1 680/4885 |
| US-20090318727-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | NBAS, HDHD5, DBF4 | ESR1 3800/4885ESR2 3636/4885MCL1 680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.