Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1402222 | 0.77 | TSHR (0.30) | TSHR | |
| SCHEMBL8603645 | 0.73 | ALDH1A1 (0.30) | — | |
| SCHEMBL8509214 | 0.69 | TSHR (0.33) | TSHR | |
| SCHEMBL40958 | 0.69 | — | — | |
| SCHEMBL8558689 | 0.66 | — | — | |
| SCHEMBL991911 | 0.66 | — | — | |
| SCHEMBL252367 | 0.65 | TSHR (0.30) | TSHR | |
| SCHEMBL7262903 | 0.65 | TSHR (0.30) | TSHR | |
| SCHEMBL7858703 | 0.65 | TSHR (0.30) | TSHR | |
| SCHEMBL634591 | 0.64 | TSHR (0.36) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10131908-B2 | 5′ phosphate mimics | ALNYLAM PHARMACEUTICALS, INC. (US) | 2018-11-20 | — | — | US | disclosed |
| US-20150080457-A1 | 5' PHOSPHATE MIMICS | BANK OF AMERICA, N.A. | 2015-03-19 | — | — | US | disclosed |
| US-8927513-B2 | 5′ phosphate mimics | ALNYLAM PHARMACEUTICALS, INC. (US) | 2015-01-06 | — | — | US | disclosed |
| US-8278425-B2 | N-substituted-aminomethylene bridged bicyclic nucleic acid analogs | ISIS PHARMACEUTICALS, INC. (US) | 2012-10-02 | — | — | US | disclosed |
| EP-2170917-B1 | N-SUBSTITUTED-AMINOMETHYLENE BRIDGED BICYCLIC NUCLEIC ACID ANALOGS | ISIS PHARMACEUTICALS INC (US) | 2012-06-27 | — | — | EP | disclosed |
| US-20120157511-A1 | 5' PHOSPHATE MIMICS | ALNYLAM PHARMACEUTICALS, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| WO-2011005860-A2 | 5' PHOSPHATE MIMICS | ALNYLAM PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |
| US-20100249211-A1 | N-Substituted-Aminomethylene Bridged Bicyclic Nucleic Acid Analogs | IONIS PHARMACEUTICALS, INC. | 2010-09-30 | — | — | US | disclosed |
| EP-2170917-A2 | N-SUBSTITUTED-AMINOMETHYLENE BRIDGED BICYCLIC NUCLEIC ACID ANALOGS | Isis Pharmaceuticals, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008150729-A2 | N-SUBSTITUTED-AMINOMETHYLENE BRIDGED BICYCLIC NUCLEIC ACID ANALOGS | ISIS PHARMACEUTICALS, INC. (US) | 2008-12-11 | — | — | WO | disclosed |
| EP-0686150-B1 | Process for the preparation of C-nucleosides and C-nucleoside analogues, new C-nucleosides and C-nucleoside analogues and their use | MAX DELBRUECK CENTRUM (DE) | 1998-05-20 | — | — | EP | disclosed |
| EP-0686150-A1 | Process for the preparation of C-nucleosides and C-nucleoside analogues, new C-nucleosides and C-nucleoside analogues and their use | MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN (DE) | 1995-12-13 | — | — | EP | disclosed |
| WO-1994019327-A1 | NUCLEOSIDES, THEIR PREPARATION AND THEIR USE AS THERAPEUTIC AGENTS AND AS BUILDING BLOCKS OF SYNTHETIC OLIGONUCLEOTIDES | Max-Delbrück-Centrum für Molekulare Medizin (DE) | 1994-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157511-A1 | 5' PHOSPHATE MIMICS | NSUN2, RNGTT, RNMT | THRB 2317/4885TSHR 3336/4885 |
| US-20150080457-A1 | 5' PHOSPHATE MIMICS | NSUN2, RNGTT, RNMT | THRB 2330/4885TSHR 3344/4885 |
| US-10131908-B2 | 5′ phosphate mimics | NSUN2, RNGTT, RNMT | THRB 2281/4885TSHR 3339/4885 |
| US-20100249211-A1 | N-Substituted-Aminomethylene Bridged Bicyclic Nucleic Acid Analogs | NSUN2, RNMT, NSUN3 | THRB 4100/4885TSHR 4575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.