SCHEMBL992741

SCHEMBL992741

CC(C)NC(C)C.N#CCCOPOCCC#N

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.33
TSHR P16473 2/20 0.32
HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1328556 0.84 TDP1 (0.31) TDP1TSHR
SCHEMBL16327711 0.82 ALDH1A1 (0.41) TDP1TSHR
SCHEMBL6891499 0.80
SCHEMBL602024 0.77 TDP1 (0.35) TDP1TSHR
SCHEMBL6891504 0.77 TDP1 (0.35) TDP1TSHR
SCHEMBL9341152 0.75 HTT (0.33) TSHRHTT
SCHEMBL9792928 0.75
SCHEMBL19774819 0.73
SCHEMBL24943254 0.72 TSHR (0.33) TSHR
SCHEMBL21902649 0.72 TSHR (0.48) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12486220-B2 Method for the purification of ethylene cyanohydrin EVONIK OPERATIONS GMBH (DE) 2025-12-02 US disclosed
US-20240034715-A1 A METHOD FOR THE PURIFICATION OF ETHYLENE CYANOHYDRIN EVONIK OPERATIONS GMBH (DE) 2024-02-01 US disclosed
EP-4073031-B1 A METHOD FOR THE PURIFICATION OF ETHYLENE CYANOHYDRIN EVONIK OPERATIONS GMBH (DE) 2023-05-24 EP disclosed
WO-2022122273-A1 A METHOD FOR THE PURIFICATION OF ETHYLENE CYANOHYDRIN EVONIK OPERATIONS GMBH (DE) 2022-06-16 WO disclosed
US-10131908-B2 5′ phosphate mimics ALNYLAM PHARMACEUTICALS, INC. (US) 2018-11-20 US disclosed
US-20150080457-A1 5' PHOSPHATE MIMICS BANK OF AMERICA, N.A. 2015-03-19 US disclosed
US-8927513-B2 5′ phosphate mimics ALNYLAM PHARMACEUTICALS, INC. (US) 2015-01-06 US disclosed
EP-2551273-A1 PHOSPHORYLATION REAGENT The University of Tokyo (JP) 2013-01-30 EP disclosed
US-20120322993-A1 Phosphorylation Reagent NIPPON SHINYAKU CO., LTD. (JP) 2012-12-20 US disclosed
US-20120157511-A1 5' PHOSPHATE MIMICS ALNYLAM PHARMACEUTICALS, INC. (US) 2012-06-21 US disclosed
WO-2011005860-A2 5' PHOSPHATE MIMICS ALNYLAM PHARMACEUTICALS, INC. (US) 2011-01-13 WO disclosed
US-5256549-A Biosynthesis using blocked monomers; followed by enzymatic hydrolysis CHIRON CORPORATION (US) 1993-10-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120157511-A1 5' PHOSPHATE MIMICS NSUN2, RNGTT, RNMT TDP1 514/4885TSHR 3336/4885HTT 3996/4885
US-20150080457-A1 5' PHOSPHATE MIMICS NSUN2, RNGTT, RNMT TDP1 518/4885TSHR 3344/4885HTT 3977/4885
US-10131908-B2 5′ phosphate mimics NSUN2, RNGTT, RNMT TDP1 515/4885TSHR 3339/4885HTT 3971/4885
US-20120322993-A1 Phosphorylation Reagent CSNK2A2, CSNK2A1, CSNK2B TDP1 3038/4885TSHR 3733/4885HTT 4787/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.