Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.43 |
| ▸ | PRKACA | P17612 | 3/20 | 0.43 |
| ▸ | CLK2 | P49760 | 3/20 | 0.43 |
| ▸ | GSK3A | P49840 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.43 |
| ▸ | PLK4 | O00444 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | ROS1 | P08922 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9928265 | 0.87 | IRAK4 (0.47) | IRAK4TRPA1JAK3PRKD3MAP4K4 | |
| SCHEMBL22524312 | 0.84 | IRAK4 (0.51) | IRAK4TRPA1JAK3PRKD3MAP4K4 | |
| SCHEMBL9928270 | 0.79 | ALOX15 (0.41) | IRAK4JAK3PRKD3MAP4K4PRKACA | |
| SCHEMBL25776394 | 0.77 | TRPA1 (0.51) | IRAK4TRPA1JAK3MAP4K1CYP1A2 | |
| SCHEMBL9928268 | 0.76 | IRAK4 (0.43) | IRAK4JAK3ROCK2ROCK1BTK | |
| SCHEMBL4780230 | 0.76 | CHEK1 (0.56) | IRAK4TRPA1JAK3AURKACYP2C19 | |
| SCHEMBL9928271 | 0.73 | LRRK2 (0.36) | IRAK4JAK3STK3KDM4ELRRK2 | |
| SCHEMBL9928275 | 0.71 | EGFR (0.58) | CDK1BRAFTNNI3K | |
| SCHEMBL21106699 | 0.71 | IRAK4 (1.00) | IRAK4BTK | |
| SCHEMBL16371979 | 0.70 | IRAK4 (0.43) | IRAK4TRPA1JAK3CDK2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | UBE INDUSTRIES, LTD. (JP) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | ERBB2, EGFR, FGFR1 | IRAK4 1112/4885TRPA1 827/4885JAK3 204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.