Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 4/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | STK4 | Q13043 | 2/20 | 0.32 |
| ▸ | STK3 | Q13188 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9898012 | 0.82 | CHEK1 (0.40) | LRRK2TSHRKDM4EALDH1A1GAA | |
| SCHEMBL9928268 | 0.82 | IRAK4 (0.43) | IRAK4JAK3ALOX15AKT1 | |
| SCHEMBL9928270 | 0.80 | ALOX15 (0.41) | LRRK2IRAK4JAK3ALOX15AKT1 | |
| SCHEMBL9897735 | 0.76 | EGFR (0.49) | LRRK2 | |
| SCHEMBL9928266 | 0.73 | IRAK4 (0.54) | LRRK2IRAK4KDM4EJAK3AKT1 | |
| SCHEMBL9928265 | 0.70 | IRAK4 (0.47) | LRRK2IRAK4KDM4EJAK3STK4 | |
| SCHEMBL9928284 | 0.69 | CHEK1 (0.42) | LRRK2TSHRALOX15AKT1STK4 | |
| SCHEMBL9943097 | 0.68 | EGFR (0.43) | IRAK4HTTSTK4STK3 | |
| SCHEMBL9928304 | 0.68 | DRD4 (0.43) | TSHRKDM4EALOX15AKT1STK4 | |
| SCHEMBL9928264 | 0.67 | STK4 (0.46) | TSHRALOX15AKT1STK4STK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | UBE INDUSTRIES, LTD. (JP) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | ERBB2, EGFR, FGFR1 | LRRK2 458/4885IRAK4 1112/4885TSHR 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.