Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 5/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | MTAP | Q13126 | 3/20 | 0.35 |
| ▸ | KHK | P50053 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | STK4 | Q13043 | 2/20 | 0.35 |
| ▸ | STK3 | Q13188 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9928283 | 0.88 | DRD2 (0.46) | CHEK1DRD2DRD4DRD3LRRK2 | |
| SCHEMBL30974955 | 0.83 | ALOX15 (0.51) | CHEK1DRD2DRD4DRD3LRRK2 | |
| SCHEMBL9928287 | 0.82 | CHEK1 (0.40) | CHEK1LRRK2ALOX15AKT1IRAK4 | |
| SCHEMBL9928284 | 0.80 | CHEK1 (0.42) | CHEK1DRD2DRD4DRD3LRRK2 | |
| SCHEMBL9943127 | 0.76 | BTK (0.50) | DRD2LRRK2AKT1STK4STK3 | |
| SCHEMBL9898012 | 0.75 | CHEK1 (0.40) | CHEK1DRD2DRD4DRD3LRRK2 | |
| SCHEMBL21678540 | 0.74 | CHEK1 (0.50) | CHEK1LRRK2AKT1IRAK4KHK | |
| SCHEMBL9928285 | 0.74 | CHEK1 (0.37) | CHEK1DRD2DRD4DRD3LRRK2 | |
| SCHEMBL9928301 | 0.74 | EGFR (0.51) | — | |
| SCHEMBL4780230 | 0.74 | CHEK1 (0.56) | CHEK1AKT1IRAK4JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | UBE INDUSTRIES, LTD. (JP) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | ERBB2, EGFR, FGFR1 | CHEK1 259/4885DRD2 870/4885DRD4 644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.