Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.39 |
| ▸ | JAK3 | P52333 | 4/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 5/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.37 |
| ▸ | STK3 | Q13188 | 3/20 | 0.36 |
| ▸ | STK4 | Q13043 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9928283 | 0.86 | DRD2 (0.46) | CHEK1LRRK2AKT1LCKMET | |
| SCHEMBL9928305 | 0.82 | TTBK1 (0.39) | LRRK2JAK3JAK2JAK1TYK2 | |
| SCHEMBL9928286 | 0.82 | CHEK1 (0.40) | CHEK1LRRK2JAK3AKT1KHK | |
| SCHEMBL9943149 | 0.80 | BTK (0.42) | JAK3JAK2JAK1 | |
| SCHEMBL30974955 | 0.79 | ALOX15 (0.51) | CHEK1LRRK2JAK2AKT1STK3 | |
| SCHEMBL9896856 | 0.78 | BTK (0.40) | LRRK2JAK3JAK2JAK1STK3 | |
| SCHEMBL9896860 | 0.78 | BTK (0.40) | LRRK2JAK3JAK2JAK1STK3 | |
| SCHEMBL9896857 | 0.78 | BTK (0.40) | LRRK2JAK3JAK2JAK1STK3 | |
| SCHEMBL9928284 | 0.77 | CHEK1 (0.42) | CHEK1LRRK2AKT1STK3STK4 | |
| SCHEMBL13471644 | 0.76 | MTAP (0.37) | CHEK1LRRK2JAK3JAK2AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | UBE INDUSTRIES, LTD. (JP) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | ERBB2, EGFR, FGFR1 | CHEK1 259/4885LRRK2 458/4885JAK3 204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.