Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | PARL | Q9H300 | 1/20 | 0.39 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | XBP1 | P17861 | 4/20 | 0.38 |
| ▸ | MPI | P34949 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727540 | 0.87 | TDP1 (0.48) | TDP1ALDH1A1HSD17B10HTR6PARL | |
| SCHEMBL28987611 | 0.82 | GAA (0.45) | TDP1ALDH1A1MAPTLMNAXBP1 | |
| SCHEMBL28088043 | 0.81 | TDP1 (0.37) | TDP1ALDH1A1HSD17B10HTR6PARL | |
| SCHEMBL29269086 | 0.80 | TDP1 (0.43) | TDP1ALDH1A1HSD17B10HTR6PARL | |
| SCHEMBL8854485 | 0.76 | HSD11B1 (0.40) | ALDH1A1HSD17B10HTR6MAPTLMNA | |
| SCHEMBL27543292 | 0.75 | TSHR (0.44) | TDP1ALDH1A1HSD17B10HTR6PARL | |
| SCHEMBL1594136 | 0.73 | TSHR (0.43) | TDP1ALDH1A1HSD17B10HTR6PARL | |
| SCHEMBL94530 | 0.73 | HTR6 (0.50) | TDP1ALDH1A1HSD17B10HTR6PARL | |
| SCHEMBL8854426 | 0.73 | ATM (0.34) | TDP1ALDH1A1KMT2A | |
| SCHEMBL1593307 | 0.73 | TDP1 (0.38) | TDP1ALDH1A1HSD17B10HTR6PARL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114409706-B | Preparation method of phenyl hydrogen phosphonate and intermediate thereof | 上海医药工业研究院 | 2023-11-28 | — | — | CN | claimed |
| CN-114409706-B | Preparation method of phenyl hydrogen phosphonate and intermediate thereof | 上海医药工业研究院 | 2023-11-28 | — | — | CN | disclosed |
| CN-105998039-A | Phosphonate ester derivatives and methods of synthesis thereof | 奇默里克斯公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-102939291-B | Phosphonate ester for the toxicity with reduction for the treatment of of viral infections | 加利福尼亚大学董事会 | 2016-09-07 | — | — | CN | disclosed |
| CN-103209985-B | Phosphonate derivatives and methods of synthesis thereof | 奇默里克斯公司 | 2016-08-24 | — | — | CN | disclosed |
| US-9045524-B2 | Selective caspase inhibitors and uses thereof | NOVAGENESIS FOUNDATION (CH) | 2015-06-02 | — | — | US | disclosed |
| US-20120157394-A1 | SELECTIVE CASPASE INHIBITORS AND USES THEREOF | NEW WORLD LABORATORIES, INC. (CA) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157394-A1 | SELECTIVE CASPASE INHIBITORS AND USES THEREOF | CASP1, VIP, CASP5 | TDP1 629/4885ALDH1A1 4093/4885HSD17B10 1853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.