Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 5/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9931440 | 0.78 | JAK2 (0.46) | IRAK4MAPTMAPK1AURKARPS6KB1 | |
| SCHEMBL14575035 | 0.76 | RPS6KB1 (0.51) | AURKARPS6KB1 | |
| SCHEMBL9931348 | 0.75 | MAPT (0.41) | IRAK4MAPTMAPK1AURKARPS6KB1 | |
| SCHEMBL9930841 | 0.74 | YTHDC1 (0.35) | GAAMAPTMAPK1ALDH1A1LMNA | |
| SCHEMBL9931256 | 0.74 | ADORA1 (0.41) | MAPT | |
| SCHEMBL2312296 | 0.73 | MAPT (0.48) | IRAK4MAPTAURKARPS6KB1 | |
| SCHEMBL9930605 | 0.71 | SIRT2 (0.45) | MAPTAURKARPS6KB1KDM4EALDH1A1 | |
| SCHEMBL9930023 | 0.71 | RAF1 (0.34) | IRAK4MAPTMAPK1AURKARPS6KB1 | |
| SCHEMBL9930629 | 0.71 | MAPT (0.44) | IRAK4MAPTMAPK1RPS6KB1ALDH1A1 | |
| SCHEMBL9930746 | 0.70 | DHODH (0.49) | GAAMAPK1AURKARPS6KB1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | IRAK4 1072/4885KMO 2839/4885CDK5 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.