Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.71 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.64 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MPO | P05164 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | IL1RN | P18510 | 1/20 | 0.55 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.55 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19051500 | 1.00 | KMT2A (0.71) | KMT2AMEN1HCRTR1NPBWR1MCHR1 | |
| Hydrochloric Acid SCHEMBL9932096 | 0.99 | KMT2A (0.70) | KMT2AMEN1HCRTR1NPBWR1MCHR1 | |
| SCHEMBL9931022 | 0.94 | KMT2A (0.74) | KMT2AMEN1HCRTR1NPBWR1MCHR1 | |
| SCHEMBL9932178 | 0.94 | KMT2A (0.74) | KMT2AMEN1HCRTR1NPBWR1MCHR1 | |
| Hydrochloric Acid SCHEMBL644842 | 0.93 | KMT2A (0.72) | KMT2AMEN1HCRTR1NPBWR1MCHR1 | |
| SCHEMBL9930905 | 0.92 | MAPT (0.61) | KMT2AMEN1HCRTR1NPBWR1MCHR1 | |
| SCHEMBL16250728 | 0.92 | MEN1 (0.65) | KMT2AMEN1HCRTR1NPBWR1MCHR1 | |
| Hydrochloric Acid SCHEMBL12819288 | 0.91 | MAPT (0.60) | KMT2AMEN1HCRTR1NPBWR1MCHR1 | |
| SCHEMBL9932155 | 0.91 | MEN1 (0.59) | KMT2AMEN1HCRTR1NPBWR1MCHR1 | |
| Hydrochloric Acid SCHEMBL9931937 | 0.91 | MAPT (0.60) | KMT2AMEN1HCRTR1NPBWR1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157387-A1 | ORALLY BIOAVAILABLE D-GAMMA-GLUTAMYL-D-TRYPTOPHAN | APOTEX TECHNOLOGIES INC. (CA) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157387-A1 | ORALLY BIOAVAILABLE D-GAMMA-GLUTAMYL-D-TRYPTOPHAN | TPH1, TPH2, GLUL | KMT2A 2787/4885MEN1 1619/4885HCRTR1 520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.