Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.48 |
| ▸ | PLK1 | P53350 | 5/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMO | Q99835 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9932332 | 0.88 | ACHE (0.49) | KDRPTK2PLK1AURKBSMO | |
| SCHEMBL9932908 | 0.88 | KDR (0.48) | KDRPTK2PLK1AURKBHCAR2 | |
| SCHEMBL9931365 | 0.83 | ALDH1A1 (0.48) | KDRPTK2PLK1AURKBALDH1A1 | |
| SCHEMBL1533944 | 0.81 | SMO (0.48) | HCAR2ALDH1A1LMNAHTTSMO | |
| SCHEMBL9932684 | 0.80 | ALDH1A1 (0.46) | ALDH1A1LMNAHTTSMOHPGD | |
| SCHEMBL9932137 | 0.80 | LMNA (0.51) | KDRPTK2PLK1AURKBLMNA | |
| SCHEMBL9931840 | 0.77 | SMO (0.45) | HCAR2ALDH1A1LMNAHTTSMO | |
| SCHEMBL9932108 | 0.76 | SMO (0.63) | KDRPTK2PLK1AURKBSMO | |
| SCHEMBL9932064 | 0.74 | ALDH1A1 (0.46) | HCAR2ALDH1A1LMNAHTTSMO | |
| SCHEMBL9971218 | 0.74 | ALDH1A1 (0.46) | HCAR2ALDH1A1LMNAHTTSMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2012-06-21 | — | — | US | disclosed |
| WO-2011027249-A2 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2011-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | SMO, RB1, GLI1 | KDR 1623/4885PTK2 3203/4885PLK1 1064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.