Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.47 |
| ▸ | IDH1 | O75874 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9973905 | 0.81 | IDH1 (0.39) | IDH1CNR2ALDH1A1KDM4E | |
| SCHEMBL9935659 | 0.78 | PARP1 (0.46) | DPP4CYP3A4DPP8IDH1PARP1 | |
| SCHEMBL9933776 | 0.78 | CYP3A4 (0.47) | DPP4CYP3A4DPP8IDH1PARP1 | |
| SCHEMBL9934256 | 0.78 | IDH1 (0.48) | DPP4CYP3A4DPP8IDH1PARP1 | |
| SCHEMBL9933853 | 0.76 | PIK3CG (0.32) | DPP4CYP3A4DPP8CNR2 | |
| SCHEMBL28612494 | 0.72 | PARP1 (0.48) | DPP4CYP3A4DPP8PARP1CNR2 | |
| SCHEMBL9933768 | 0.68 | IDH1 (0.45) | IDH1PARP1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL25225949 | 0.68 | KDM4E (0.59) | PARP1MAPK1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL9933420 | 0.68 | MEN1 (0.32) | IDH1 | |
| SCHEMBL2144299 | 0.67 | PARP1 (0.45) | IDH1PARP1AOC3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157494-A1 | ISOINDOLYL COMPOUNDS | HARRIS III RALPH NEW (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157494-A1 | ISOINDOLYL COMPOUNDS | P2RX7, P2RX3, P2RX1 | DPP4 1047/4885CYP3A4 442/4885DPP8 962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.