Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1948769 | 0.82 | S100A4 (0.42) | IDH1ALDH1A1HTTRAB9ALMNA | |
| SCHEMBL9934256 | 0.79 | IDH1 (0.48) | IDH1PARP1ALDH1A1HTTRAB9A | |
| SCHEMBL30908473 | 0.78 | IDH1 (0.48) | IDH1RAB9AKMT2AMAPTHPGD | |
| SCHEMBL31598720 | 0.78 | S100A4 (0.46) | ALDH1A1HTTRAB9ALMNAS100A4 | |
| SCHEMBL5906644 | 0.78 | S100A4 (0.46) | ALDH1A1HTTRAB9ALMNAS100A4 | |
| SCHEMBL9933485 | 0.78 | S100A4 (0.40) | ALDH1A1HTTRAB9ALMNAAGTR1 | |
| SCHEMBL9932906 | 0.78 | S100A4 (0.40) | ALDH1A1HTTRAB9ALMNAAGTR1 | |
| SCHEMBL16706320 | 0.76 | GAA (0.38) | ALDH1A1HTTRAB9ALMNAKMT2A | |
| SCHEMBL14348206 | 0.76 | DHPS (0.54) | IDH1ALDH1A1HTTLMNAKMT2A | |
| SCHEMBL7950879 | 0.76 | ALDH1A1 (0.42) | ALDH1A1HTTRAB9ALMNAS100A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157494-A1 | ISOINDOLYL COMPOUNDS | HARRIS III RALPH NEW (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157494-A1 | ISOINDOLYL COMPOUNDS | P2RX7, P2RX3, P2RX1 | IDH1 1995/4885PARP1 2652/4885ALDH1A1 820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.