SCHEMBL9936673

SCHEMBL9936673

CC(C)NC(=O)c1ccc[nH]c1=S

nearest known ligand 0.56

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.56
GAA P10253 3/20 0.56
HTT P42858 2/20 0.56
APOBEC3G Q9HC16 1/20 0.56
KDM4E B2RXH2 2/20 0.56
MAPT P10636 1/20 0.56
PKM P14618 1/20 0.44
GLS O94925 1/20 0.41
ALOX5 P09917 1/20 0.41
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21812523 0.86 GAA (0.56) ALDH1A1GAAHTTAPOBEC3GKDM4E
SCHEMBL21812521 0.86 GAA (0.56) ALDH1A1GAAHTTAPOBEC3GKDM4E
SCHEMBL9936974 0.83 GAA (0.45) ALDH1A1GAAHTTAPOBEC3GKDM4E
SCHEMBL9936971 0.83 GAA (0.45) ALDH1A1GAAHTTAPOBEC3GKDM4E
SCHEMBL9936595 0.81 GAA (0.61) ALDH1A1GAAHTTAPOBEC3GKDM4E
SCHEMBL9936605 0.81 GAA (0.53) ALDH1A1GAAHTTAPOBEC3GKDM4E
SCHEMBL9936906 0.80 GAA (0.51) ALDH1A1GAAHTTAPOBEC3GKDM4E
SCHEMBL13485775 0.79 GAA (0.63) ALDH1A1GAAHTTAPOBEC3GKDM4E
SCHEMBL9936614 0.77 GAA (0.56) ALDH1A1GAAHTTAPOBEC3GKDM4E
SCHEMBL12376697 0.75 KDM4E (0.49) KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2651897-B1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS OREAL (FR) 2020-04-01 EP claimed
EP-2651897-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'Oréal (FR) 2013-10-23 EP claimed
WO-2012080075-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2012-06-21 WO claimed
US-20240293301-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2024-09-05 US disclosed
US-20210401709-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'ORÉAL (FR) 2021-12-30 US disclosed
US-11052028-B2 Process for depigmenting keratin materials using thiopyridinone compounds L'OREAL (FR) 2021-07-06 US disclosed
EP-2651897-B1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS OREAL (FR) 2020-04-01 EP disclosed
US-20160045420-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2016-02-18 US disclosed
US-20160045420-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2016-02-18 US disclosed
US-9138392-B2 Process for depigmenting keratin materials using thiopyridinone compounds L'OREAL (FR) 2015-09-22 US disclosed
US-9138392-B2 Process for depigmenting keratin materials using thiopyridinone compounds L'OREAL (FR) 2015-09-22 US disclosed
WO-2012080075-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2012-06-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160045420-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS CBR3, RTN3, HRH4 ALDH1A1 1647/4885GAA 4768/4885HTT 1773/4885
US-20240293301-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS CBR3, RTN3, HRH4 ALDH1A1 1679/4885GAA 4771/4885HTT 1842/4885
US-20210401709-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS CBR3, HRH4, RTN3 ALDH1A1 1705/4885GAA 4751/4885HTT 1473/4885
US-11052028-B2 Process for depigmenting keratin materials using thiopyridinone compounds KRT18, PKN1, PTMA ALDH1A1 1269/4885GAA 2542/4885HTT 1114/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.