SCHEMBL9936974

SCHEMBL9936974

CCOC(=O)[C@H](C)NC(=O)c1ccc[nH]c1=S

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.45
KDM4E B2RXH2 2/20 0.45
MAPT P10636 1/20 0.45
ALDH1A1 P00352 2/20 0.44
HTT P42858 1/20 0.44
APOBEC3G Q9HC16 1/20 0.44
HPGD P15428 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9936971 1.00 GAA (0.45) GAAKDM4EMAPTALDH1A1HTT
SCHEMBL9936673 0.83 ALDH1A1 (0.56) GAAKDM4EMAPTALDH1A1HTT
SCHEMBL21812521 0.82 GAA (0.56) GAAKDM4EMAPTALDH1A1HTT
SCHEMBL21812523 0.82 GAA (0.56) GAAKDM4EMAPTALDH1A1HTT
SCHEMBL9970770 0.81 GAA (0.47) GAAKDM4EMAPTALDH1A1
SCHEMBL17507186 0.81 GAA (0.47) GAAKDM4EMAPTALDH1A1
SCHEMBL27504171 0.81 KDM4E (0.47) KDM4E
SCHEMBL20366922 0.77 THRB (0.54) GAAKDM4EMAPTALDH1A1HTT
SCHEMBL18985198 0.77 ALDH1A1 (0.49) GAAKDM4EMAPTALDH1A1HTT
SCHEMBL7368017 0.77 ACE (0.47) GAAALDH1A1HTTAPOBEC3GSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12521333-B2 Composition comprising compound of thiopyridinone type and polyglyceryl-based emulsifiers L'OREAL (FR) 2026-01-13 US claimed
US-20250381116-A1 SOLUBILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME OREAL (FR) 2025-12-18 US claimed
US-20250381115-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME OREAL (FR) 2025-12-18 US claimed
US-20250367096-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME OREAL (FR) 2025-12-04 US claimed
US-20250205131-A1 COSMETIC COMPOSITION COMPRISING THIOPYRIDINONE COMPOUNDS, REDUCING AGENT AND ARGININE L'OREAL (FR) 2025-06-26 US claimed
US-12226506-B2 Cosmetic composition comprising natural emulsifiers and thiopyridinone compounds L'OREAL (FR) 2025-02-18 US claimed
US-20230404879-A1 ENHANCING PHOTOSTABILITY OF THIOPYRIDINONE COMPOUND WITHOUT THE USE OF UV FILTERS L'OREAL (FR) 2023-12-21 US claimed
US-20230404883-A1 COSMETIC COMPOSITION COMPRISING NATURAL EMULSIFIERS AND THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2023-12-21 US claimed
US-20230404884-A1 COSMETIC COMPOSITION COMPRISING HYDROPHILIC ANTIOXIDANTS AND THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2023-12-21 US claimed
US-20230404882-A1 COMPOSITION COMPRISING COMPOUND OF THIOPYRIDINONE TYPE AND POLYGLYCERYL-BASED EMULSIFIERS L'OREAL (FR) 2023-12-21 US claimed
EP-2651897-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'Oréal (FR) 2013-10-23 EP claimed
WO-2012080075-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2012-06-21 WO claimed
US-12521333-B2 Composition comprising compound of thiopyridinone type and polyglyceryl-based emulsifiers L'OREAL (FR) 2026-01-13 US disclosed
US-20250381115-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME OREAL (FR) 2025-12-18 US disclosed
US-20250381116-A1 SOLUBILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME OREAL (FR) 2025-12-18 US disclosed
US-20250375367-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME OREAL (FR) 2025-12-11 US disclosed
US-20230404883-A1 COSMETIC COMPOSITION COMPRISING NATURAL EMULSIFIERS AND THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2023-12-21 US disclosed
US-20230404882-A1 COMPOSITION COMPRISING COMPOUND OF THIOPYRIDINONE TYPE AND POLYGLYCERYL-BASED EMULSIFIERS L'OREAL (FR) 2023-12-21 US disclosed
US-20230404884-A1 COSMETIC COMPOSITION COMPRISING HYDROPHILIC ANTIOXIDANTS AND THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2023-12-21 US disclosed
US-20230404879-A1 ENHANCING PHOTOSTABILITY OF THIOPYRIDINONE COMPOUND WITHOUT THE USE OF UV FILTERS L'OREAL (FR) 2023-12-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230404882-A1 COMPOSITION COMPRISING COMPOUND OF THIOPYRIDINONE TYPE AND POLYGLYCERYL-BASED EMULSIFIERS PPARG, PHOSPHO1, SQLE GAA 1405/4885KDM4E 1549/4885MAPT 2629/4885
US-20230404884-A1 COSMETIC COMPOSITION COMPRISING HYDROPHILIC ANTIOXIDANTS AND THIOPYRIDINONE COMPOUNDS TPO, LPO, OGG1 GAA 2008/4885KDM4E 896/4885MAPT 3781/4885
US-20250375367-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME TPMT, CRY1, TDP1 GAA 3382/4885KDM4E 545/4885MAPT 90/4885
US-20230404883-A1 COSMETIC COMPOSITION COMPRISING NATURAL EMULSIFIERS AND THIOPYRIDINONE COMPOUNDS PPARG, PHOSPHO1, POLQ GAA 2225/4885KDM4E 1820/4885MAPT 3678/4885
US-20250367096-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME TPMT, DHPS, MTAP GAA 3858/4885KDM4E 1341/4885MAPT 518/4885
US-20250381115-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME TPMT, TPR, TYMP GAA 3088/4885KDM4E 1410/4885MAPT 750/4885
US-12226506-B2 Cosmetic composition comprising natural emulsifiers and thiopyridinone compounds PPARG, PHOSPHO1, POLQ GAA 2225/4885KDM4E 1820/4885MAPT 3678/4885
US-20250205131-A1 COSMETIC COMPOSITION COMPRISING THIOPYRIDINONE COMPOUNDS, REDUCING AGENT AND ARGININE PRMT1, ARG1, PRMT5 GAA 4238/4885KDM4E 200/4885MAPT 1415/4885
US-20250381116-A1 SOLUBILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME TBCB, CCNB3, CYP24A1 GAA 4523/4885KDM4E 1771/4885MAPT 2277/4885
US-20230404879-A1 ENHANCING PHOTOSTABILITY OF THIOPYRIDINONE COMPOUND WITHOUT THE USE OF UV FILTERS TYR, TST, TSN GAA 2602/4885KDM4E 209/4885MAPT 2465/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.