SCHEMBL9936971

SCHEMBL9936971

CCOC(=O)C(C)NC(=O)c1ccc[nH]c1=S

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.45
KDM4E B2RXH2 2/20 0.45
MAPT P10636 1/20 0.45
ALDH1A1 P00352 2/20 0.44
HTT P42858 1/20 0.44
APOBEC3G Q9HC16 1/20 0.44
HPGD P15428 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9936974 1.00 GAA (0.45) GAAKDM4EMAPTALDH1A1HTT
SCHEMBL9936673 0.83 ALDH1A1 (0.56) GAAKDM4EMAPTALDH1A1HTT
SCHEMBL21812521 0.82 GAA (0.56) GAAKDM4EMAPTALDH1A1HTT
SCHEMBL21812523 0.82 GAA (0.56) GAAKDM4EMAPTALDH1A1HTT
SCHEMBL9970770 0.81 GAA (0.47) GAAKDM4EMAPTALDH1A1
SCHEMBL17507186 0.81 GAA (0.47) GAAKDM4EMAPTALDH1A1
SCHEMBL27504171 0.81 KDM4E (0.47) KDM4E
SCHEMBL20366922 0.77 THRB (0.54) GAAKDM4EMAPTALDH1A1HTT
SCHEMBL18985198 0.77 ALDH1A1 (0.49) GAAKDM4EMAPTALDH1A1HTT
SCHEMBL7368017 0.77 ACE (0.47) GAAALDH1A1HTTAPOBEC3GSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2651897-B1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS OREAL (FR) 2020-04-01 EP claimed
EP-2651897-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'Oréal (FR) 2013-10-23 EP claimed
WO-2012080075-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2012-06-21 WO claimed
US-20230404882-A1 COMPOSITION COMPRISING COMPOUND OF THIOPYRIDINONE TYPE AND POLYGLYCERYL-BASED EMULSIFIERS L'OREAL (FR) 2023-12-21 US disclosed
US-20210401709-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'ORÉAL (FR) 2021-12-30 US disclosed
US-11052028-B2 Process for depigmenting keratin materials using thiopyridinone compounds L'OREAL (FR) 2021-07-06 US disclosed
EP-2651897-B1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS OREAL (FR) 2020-04-01 EP disclosed
EP-3390363-B1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS OREAL (FR) 2019-09-18 EP disclosed
WO-2017102349-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2017-06-22 WO disclosed
US-20160045420-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2016-02-18 US disclosed
US-20160045420-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2016-02-18 US disclosed
US-9138392-B2 Process for depigmenting keratin materials using thiopyridinone compounds L'OREAL (FR) 2015-09-22 US disclosed
US-9138392-B2 Process for depigmenting keratin materials using thiopyridinone compounds L'OREAL (FR) 2015-09-22 US disclosed
WO-2012080075-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2012-06-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230404882-A1 COMPOSITION COMPRISING COMPOUND OF THIOPYRIDINONE TYPE AND POLYGLYCERYL-BASED EMULSIFIERS PPARG, PHOSPHO1, SQLE GAA 1405/4885KDM4E 1549/4885MAPT 2629/4885
US-20160045420-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS CBR3, RTN3, HRH4 GAA 4768/4885KDM4E 588/4885MAPT 1622/4885
US-20210401709-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS CBR3, HRH4, RTN3 GAA 4751/4885KDM4E 425/4885MAPT 1383/4885
US-11052028-B2 Process for depigmenting keratin materials using thiopyridinone compounds KRT18, PKN1, PTMA GAA 2542/4885KDM4E 126/4885MAPT 232/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.