Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL457249 | 0.83 | RAB9A (0.48) | HPGDHRH3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30682441 | 0.82 | HPGD (0.59) | HPGDHRH3NPC1RAB9AP2RX7 | |
| SCHEMBL4640347 | 0.79 | JAK2 (0.46) | HPGDNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL29077678 | 0.79 | HPGD (0.71) | HPGDNPC1RAB9AP2RX7SMN1; SMN2 | |
| SCHEMBL28378463 | 0.77 | HPGD (0.69) | HPGDHRH3NPC1RAB9AP2RX7 | |
| SCHEMBL10282412 | 0.76 | RAB9A (0.86) | HPGDNPC1RAB9AP2RX7SMN1; SMN2 | |
| SCHEMBL1820539 | 0.76 | HPGD (0.68) | HPGDHRH3NPC1RAB9AP2RX7 | |
| SCHEMBL4516890 | 0.76 | HPGD (0.68) | HPGDHRH3NPC1RAB9AP2RX7 | |
| SCHEMBL2319509 | 0.75 | RAB9A (0.56) | HPGDHRH3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12672349 | 0.75 | HPGD (0.66) | HPGDHRH3NPC1RAB9AP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651948-A1 | IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT HYPERPROLIFERATIVE DISORDERS | Bayer Intellectual Property GmbH (DE) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012080229-A1 | IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT HYPERPROLIFERATIVE DISORDERS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-06-21 | — | — | WO | disclosed |