Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 8/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20428017 | 0.87 | HPGD (0.45) | HPGDRECQLPTPN2PTPN1PTPN6 | |
| SCHEMBL9971129 | 0.81 | HPGD (0.46) | HPGDRECQLPTPN2PTPN1PTPN6 | |
| SCHEMBL1015830 | 0.79 | MAPT (0.36) | RECQLKMT2AKDM4EMAPT | |
| SCHEMBL31587724 | 0.79 | MAPT (0.36) | RECQLKMT2AKDM4EMAPT | |
| SCHEMBL1015828 | 0.79 | MAPT (0.36) | RECQLKMT2AKDM4EMAPT | |
| SCHEMBL2515709 | 0.78 | — | — | |
| SCHEMBL2515711 | 0.78 | — | — | |
| SCHEMBL1014889 | 0.76 | MAPT (0.35) | MAPT | |
| SCHEMBL1016151 | 0.76 | CES2 (0.39) | ALDH1A1MAPTRAB9A | |
| SCHEMBL17109784 | 0.76 | HPGD (0.55) | HPGDRECQLPTPN2PTPN1PTPN6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012082947-A1 | COMPOUNDS AND COMPOSITIONS AS TGR5 AGONISTS | IRM LLC (BM) | 2012-06-21 | — | — | WO | disclosed |