Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.35 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.35 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2551861 | 0.96 | ALDH1A1 (0.40) | KIF11ALDH1A1TSHRCES2CES1 | |
| SCHEMBL14811633 | 0.93 | ALDH1A1 (0.39) | KIF11ALDH1A1TSHRCES2CES1 | |
| SCHEMBL23145206 | 0.88 | AHR (0.35) | KIF11ALDH1A1TSHRCES2CES1 | |
| SCHEMBL2557952 | 0.78 | — | — | |
| SCHEMBL2548631 | 0.77 | TSHR (0.48) | KIF11ALDH1A1TSHR | |
| SCHEMBL3817848 | 0.75 | ALDH1A1 (0.39) | KIF11ALDH1A1TSHRCES2CES1 | |
| Hydrochloric Acid SCHEMBL29591258 | 0.75 | TSHR (0.46) | KIF11ALDH1A1TSHR | |
| SCHEMBL29670197 | 0.75 | TSHR (0.46) | KIF11ALDH1A1TSHR | |
| SCHEMBL2550800 | 0.73 | CES2 (0.38) | KIF11CES2PDE2A | |
| Hydrochloric Acid SCHEMBL18796541 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11760741-B2 | Pro-drugs of eliglustat | KASHIV BIOSCIENCES, LLC (US) | 2023-09-19 | — | — | US | disclosed |
| US-20220389310-A1 | LUMINESCENT MATERIALS AND METHODS THEREOF | UNIVERSITY OF WASHINGTON (US) | 2022-12-08 | — | — | US | disclosed |
| WO-2021062035-A1 | LUMINESCENT MATERIALS AND METHODS THEREOF | UNIVERSITY OF WASHINGTON (US) | 2021-04-01 | — | — | WO | disclosed |
| WO-2012079583-A1 | SYSTEM PROVIDING CONTROLLED DELIVERY OF GASEOUS CO FOR CARBONYLATION REACTIONS | AARHUS UNIVERSITET (DK) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11760741-B2 | Pro-drugs of eliglustat | GCG, GLP1R, PROKR1 | KIF11 2009/4885ALDH1A1 925/4885TSHR 3101/4885 |
| US-20220389310-A1 | LUMINESCENT MATERIALS AND METHODS THEREOF | TYR, GSTA2, CYBA | KIF11 3462/4885ALDH1A1 479/4885TSHR 4145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.