Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CASP2 | P42575 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14753609 | 0.83 | CYP3A4 (0.51) | CYP3A4CYP2C19L3MBTL1HPGDEPHX2 | |
| SCHEMBL1690435 | 0.78 | HPGD (0.68) | CYP3A4HPGDALDH1A1MEN1GAA | |
| SCHEMBL28124071 | 0.76 | NAMPT (0.50) | CYP3A4CYP2C19L3MBTL1HPGDALDH1A1 | |
| SCHEMBL2092775 | 0.74 | CYP3A4 (0.61) | CYP3A4CYP2C19L3MBTL1HPGDEPHX2 | |
| SCHEMBL24324500 | 0.74 | CYP3A4 (0.42) | CYP3A4CYP2C19L3MBTL1HPGDALDH1A1 | |
| SCHEMBL5861280 | 0.74 | HTT (0.47) | CYP3A4CYP2C19L3MBTL1HPGDALDH1A1 | |
| SCHEMBL14753612 | 0.74 | HDAC3 (0.46) | CYP3A4CYP2C19L3MBTL1HPGDALDH1A1 | |
| SCHEMBL1690615 | 0.74 | CYP3A4 (0.42) | CYP3A4CYP2C19L3MBTL1HPGDALDH1A1 | |
| SCHEMBL18134836 | 0.73 | CYP3A4 (0.65) | CYP3A4CYP2C19L3MBTL1HPGDEPHX2 | |
| SCHEMBL770934 | 0.73 | CYP3A4 (0.87) | CYP3A4CYP2C19L3MBTL1HPGDEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10290819-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2019-05-14 | — | — | US | disclosed |
| US-20130284977-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2013-10-31 | — | — | US | disclosed |
| WO-2012079741-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10290819-B2 | Metal complexes | PICALM, IMMT, IKZF3 | CYP3A4 1870/4885CYP2C19 3782/4885L3MBTL1 3693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.