Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | LIPA | P38571 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30016965 | 0.92 | THRA (0.36) | THRATHRBDGAT1NR1H2 | |
| SCHEMBL10681272 | 0.90 | MMP1 (0.41) | MMP1MMP9MMP13ADAM17FKBP1A | |
| SCHEMBL595697 | 0.88 | ALOX15 (0.39) | SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3160421 | 0.87 | ALOX15 (0.38) | TDP1 | |
| SCHEMBL16369980 | 0.83 | THRA (0.40) | THRATHRBDGAT1MMP1MMP9 | |
| SCHEMBL4716172 | 0.83 | THRA (0.40) | THRATHRBDGAT1MMP1MMP9 | |
| SCHEMBL3169200 | 0.82 | SMN1; SMN2 (0.36) | KDM4ESMN1; SMN2 | |
| SCHEMBL595189 | 0.79 | KDM4E (0.50) | NR1H2KDM4ESMN1; SMN2 | |
| SCHEMBL20241792 | 0.78 | THRA (0.37) | THRATHRBDGAT1MMP1MMP9 | |
| SCHEMBL7219547 | 0.77 | THRA (0.35) | THRATHRBDGAT1MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463282-A1 | 4-Benzylamino-1-carboxyacyl-piperidine derivatives as CETP inhibitors useful for the treatment of diseases such as hyperlipidemia or arteriosclerosis | Novartis AG (CH) | 2012-06-13 | — | — | EP | disclosed |