Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26319974 | 0.77 | CYP1A2 (0.51) | HIF1ANPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL3160952 | 0.73 | KDM4E (0.40) | KDM4EALDH1A1 | |
| SCHEMBL895535 | 0.72 | HIF1A (0.49) | HIF1ANPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL2722250 | 0.69 | ALDH1A1 (0.57) | SMN1; SMN2CYP1A2CYP2C19TDP1ALDH1A1 | |
| SCHEMBL5493166 | 0.69 | SMN1; SMN2 (0.56) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL403460 | 0.69 | CYP1A2 (0.56) | SMN1; SMN2CYP1A2CYP2C19TDP1ALDH1A1 | |
| SCHEMBL3161028 | 0.69 | KDM4E (0.41) | NPC1POLBRAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL27763463 | 0.68 | MAPK1 (0.38) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2C19 | |
| Hydrochloric Acid SCHEMBL3001066 | 0.68 | SMN1; SMN2 (0.54) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL29499090 | 0.67 | SMN1; SMN2 (0.62) | SMN1; SMN2CYP1A2CYP2C19TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651930-A1 | BIARYLAMIDE INHIBITORS OF LEUKOTRIENE PRODUCTION | Boehringer Ingelheim International GmbH (DE) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012082817-A1 | BIARYLAMIDE INHIBITORS OF LEUKOTRIENE PRODUCTION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-21 | — | — | WO | disclosed |