Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.42 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.42 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9971187 | 0.84 | KCNA5 (0.42) | MALT1IDO1BRD4PDK2LMNA | |
| SCHEMBL29323153 | 0.83 | MALT1 (0.47) | MALT1IDO1BRD4PDK2LMNA | |
| SCHEMBL7006722 | 0.81 | MALT1 (0.54) | MALT1IDO1BRD4TPSAB1TPSD1 | |
| SCHEMBL4392860 | 0.81 | MALT1 (0.49) | MALT1IDO1BRD4PDK2LMNA | |
| SCHEMBL24257146 | 0.80 | SYK (0.51) | MALT1IDO1BRD4PDK2LMNA | |
| SCHEMBL15570773 | 0.80 | ALDH1A1 (0.49) | MALT1BRD4 | |
| SCHEMBL15570774 | 0.80 | ALDH1A1 (0.49) | MALT1BRD4 | |
| SCHEMBL5434942 | 0.80 | MEN1 (0.51) | MALT1IDO1BRD4LMNAPKM | |
| SCHEMBL18085408 | 0.80 | MALT1 (0.49) | MALT1BRD4TPSAB1TPSD1TPSG1 | |
| SCHEMBL21973175 | 0.80 | MALT1 (0.49) | MALT1BRD4TPSAB1TPSD1TPSG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9402914-B2 | Membrane lytic poly(amido amine) polymers for the delivery of oligonucleotides | SIRNA THERAPEUTICS, INC. (US) | 2016-08-02 | — | — | US | disclosed |
| US-9402914-B2 | Membrane lytic poly(amido amine) polymers for the delivery of oligonucleotides | SIRNA THERAPEUTICS, INC. (US) | 2016-08-02 | — | — | US | disclosed |
| US-9402914-B2 | Membrane lytic poly(amido amine) polymers for the delivery of oligonucleotides | SIRNA THERAPEUTICS, INC. (US) | 2016-08-02 | — | — | US | disclosed |
| US-20150165058-A1 | MEMBRANE LYTIC POLY(AMIDO AMINE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES | BANK OF AMERICA, N.A. | 2015-06-18 | — | — | US | disclosed |
| US-20150165058-A1 | MEMBRANE LYTIC POLY(AMIDO AMINE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES | BANK OF AMERICA, N.A. | 2015-06-18 | — | — | US | disclosed |
| US-20150165058-A1 | MEMBRANE LYTIC POLY(AMIDO AMINE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES | BANK OF AMERICA, N.A. | 2015-06-18 | — | — | US | disclosed |
| US-8901101-B2 | Membrane lytic poly(amido amine) polymers for the delivery of oligonucleotides | SIRNA THERAPEUTICS, INC. (US) | 2014-12-02 | — | — | US | disclosed |
| US-8901101-B2 | Membrane lytic poly(amido amine) polymers for the delivery of oligonucleotides | SIRNA THERAPEUTICS, INC. (US) | 2014-12-02 | — | — | US | disclosed |
| US-8901101-B2 | Membrane lytic poly(amido amine) polymers for the delivery of oligonucleotides | SIRNA THERAPEUTICS, INC. (US) | 2014-12-02 | — | — | US | disclosed |
| US-20130289207-A1 | MEMBRANE LYTIC POLY(AMIDO AMINE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES | BANK OF AMERICA, N.A. | 2013-10-31 | — | — | US | disclosed |
| US-20130289207-A1 | MEMBRANE LYTIC POLY(AMIDO AMINE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES | BANK OF AMERICA, N.A. | 2013-10-31 | — | — | US | disclosed |
| US-20130289207-A1 | MEMBRANE LYTIC POLY(AMIDO AMINE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES | BANK OF AMERICA, N.A. | 2013-10-31 | — | — | US | disclosed |
| WO-2012082574-A1 | MEMBRANE LYTIC POLY(AMIDO AMINE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES | MERCK SHARP & DOHME CORP. (US) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150165058-A1 | MEMBRANE LYTIC POLY(AMIDO AMINE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES | PUF60, PHOSPHO1, PARG | MALT1 2081/4885IDO1 4332/4885BRD4 3846/4885 |
| US-20130289207-A1 | MEMBRANE LYTIC POLY(AMIDO AMINE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES | PUF60, PHOSPHO1, PARG | MALT1 2081/4885IDO1 4332/4885BRD4 3846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.