Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 4/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30174945 | 0.93 | L3MBTL1 (0.42) | BCHEKMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL9941131 | 0.87 | KMT2A (0.37) | BCHEKMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL598928 | 0.84 | SMN1; SMN2 (0.45) | KMT2AMEN1L3MBTL1SMN1; SMN2 | |
| SCHEMBL598929 | 0.84 | SMN1; SMN2 (0.45) | KMT2AMEN1L3MBTL1SMN1; SMN2 | |
| SCHEMBL1742832 | 0.84 | P2RX7 (0.43) | KMT2APOLBALDH1A1 | |
| SCHEMBL16975191 | 0.81 | MME (0.38) | CHRM3KMT2AALDH1A1 | |
| SCHEMBL598705 | 0.81 | KLK7 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL598704 | 0.81 | KLK7 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL9966147 | 0.80 | HCRTR1 (0.39) | HCRTR1HCRTR2KMT2AMEN1L3MBTL1 | |
| SCHEMBL598932 | 0.80 | BRD4 (0.42) | HCRTR1HCRTR2KMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651896-A1 | NEPRILYSIN INHIBITORS | Theravance, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012082853-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-06-21 | — | — | WO | disclosed |