Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 4/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16930525 | 0.84 | USP30 (0.36) | MMECHRM3ACEALDH1A1FFAR4 | |
| SCHEMBL16930524 | 0.84 | USP30 (0.36) | MMECHRM3ACEALDH1A1FFAR4 | |
| SCHEMBL9941763 | 0.81 | CHRM2 (0.39) | CHRM3ALDH1A1KMT2A | |
| SCHEMBL16939237 | 0.81 | CHRM3 (0.36) | MMECHRM3ACEFFAR4FFAR1 | |
| SCHEMBL9941131 | 0.79 | KMT2A (0.37) | ALDH1A1KMT2A | |
| SCHEMBL30174945 | 0.79 | L3MBTL1 (0.42) | ALDH1A1KMT2A | |
| SCHEMBL1742832 | 0.79 | P2RX7 (0.43) | ALDH1A1KMT2A | |
| SCHEMBL14902419 | 0.76 | MME (0.38) | MMEALDH1A1KMT2ACNR1 | |
| SCHEMBL16939238 | 0.76 | MME (0.36) | MMECHRM3ACEFFAR4 | |
| SCHEMBL14900465 | 0.73 | RORC (0.40) | MMEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099678-A1 | NEPRILYSIN INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2016-12-07 | — | — | EP | disclosed |
| WO-2015116786-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-08-06 | — | — | WO | disclosed |