Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.46 |
| ▸ | CES2 | O00748 | 2/20 | 0.43 |
| ▸ | TACR1 | P25103 | 7/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL265045 | 1.00 | PDE2A (0.46) | PDE2ACES2TACR1PNMTIDO1 | |
| SCHEMBL435108 | 1.00 | PDE2A (0.46) | PDE2ACES2TACR1PNMTIDO1 | |
| SCHEMBL9386794 | 0.96 | PDE2A (0.43) | PDE2ACES2TACR1PNMTIDO1 | |
| SCHEMBL23895404 | 0.92 | PDE2A (0.41) | PDE2ACES2TACR1PNMTIDO1 | |
| SCHEMBL7250729 | 0.88 | PDE2A (0.39) | PDE2ACES2TACR1 | |
| SCHEMBL5199897 | 0.87 | PDE2A (0.41) | PDE2ACES2TACR1PNMTMAPT | |
| SCHEMBL1295024 | 0.87 | PDE2A (0.41) | PDE2ACES2TACR1PNMTPTPN5 | |
| SCHEMBL12118738 | 0.87 | PDE2A (0.41) | PDE2ACES2TACR1PNMTMAPT | |
| SCHEMBL31560879 | 0.87 | PDE2A (0.41) | PDE2ACES2TACR1PNMTPTPN5 | |
| SCHEMBL15216810 | 0.87 | PDE2A (0.41) | PDE2ACES2TACR1PNMTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 157 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112048538-A | Method for preparing (S) - [3, 5-bis (trifluoromethyl) phenyl ] ethanol by using Verticillium terrestris | 浙江工业大学 | 2020-12-08 | — | — | CN | claimed |
| EP-2578574-B1 | OPTICALLY ACTIVE DIBENZYLAMINE DERIVATIVE, AND MANUFACTURING METHOD FOR SAME | KOWA CO (JP) | 2016-04-27 | — | — | EP | claimed |
| US-9272966-B2 | Method for preparing optically active 1-bromo-1[3,5-bis(trifluoromethyl)phenyl]ethane | KOWA COMPANY, LTD. (JP) | 2016-03-01 | — | — | US | claimed |
| CN-103773724-B | Rhodococcus XS1012 and preparing the application in chiral alcohol | JIANG University OF TECHNOLOGY (CN) | 2016-01-20 | — | — | CN | claimed |
| US-8906895-B2 | Optically active dibenzylamine derivative, and method for preparing thereof | KOWA COMPANY, LTD. (JP) | 2014-12-09 | — | — | US | claimed |
| CN-103773724-A | Rhodococcus erythropolis XS1012 and application thereof in preparation of chiral alcohol | UNIV ZHEJIANG TECHNOLOGY | 2014-05-07 | — | — | CN | claimed |
| US-20130225814-A1 | OPTICALLY ACTIVE DIBENZYLAMINE DERIVATIVE, AND METHOD FOR PREPARING THEREOF | KOWA COMPANY, LTD. (JP) | 2013-08-29 | — | — | US | claimed |
| US-20130190540-A1 | METHOD FOR PREPARING OPTICALLY ACTIVE 1-BROMO-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANE | KOWA COMPANY, LTD. (JP) | 2013-07-25 | — | — | US | claimed |
| EP-2597079-A1 | METHOD FOR PRODUCING OPTICALLY ACTIVE 1-BROMO-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANE | Kowa Company Ltd. (JP) | 2013-05-29 | — | — | EP | claimed |
| EP-2578574-A1 | OPTICALLY ACTIVE DIBENZYLAMINE DERIVATIVE, AND MANUFACTURING METHOD FOR SAME | Kowa Company, Ltd. (JP) | 2013-04-10 | — | — | EP | claimed |
| US-20260085334-A1 | ENGINEERED KETOREDUCTASES FOR THE PREPARATION OF CHIRAL ALCOHOLS AND METHODS THEREOF | ENZYMASTER (NINGBO) BIO-ENGINEERING CO., LTD. (CN) | 2026-03-26 | — | — | US | disclosed |
| EP-4551693-A1 | ENGINEERED KETOREDUCTASES FOR THE PREPARATION OF CHIRAL ALCOHOLS AND METHODS THEREOF | Enzymaster (Ningbo) Bio-Engineering Co., Ltd. (CN) | 2025-05-14 | — | — | EP | disclosed |
| CN-118667775-A | Biocatalyst and method for synthesizing chiral alcohol compound | 宁波酶赛生物工程有限公司 | 2024-09-20 | — | — | CN | disclosed |
| WO-2024188081-A1 | BIOCATALYST AND METHOD FOR SYNTHESIZING CHIRAL ALCOHOL COMPOUNDS | ENZYMASTER (NINGBO) BIO-ENGINEERING CO., LTD. (CN) | 2024-09-19 | — | — | WO | disclosed |
| CN-113584090-B | Biological preparation method of chemokine CCR 5 antagonist AD101 chiral intermediate | 浙江工业大学 | 2024-07-19 | — | — | CN | disclosed |
| EP-1448788-A4 | PROCESS FOR THE SYNTHESIS OF (R)-1-(3,5-BIS(TRIFLUOROMETHYL)-PHENYL)ETHAN-1-OL AND ESTERS THEREOF BY DYNAMIC KINETIC RESOLUTION | MERCK & CO INC (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005095628-A1 | METHOD FOR THE PRODUCTION OF CHIRAL, SECONDARY ALCOHOLS | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) | 2005-10-13 | — | — | WO | disclosed |
| US-20050165083-A1 | Hydroisoindoline tachykinin receptor antagonists | VYNE THERAPEUTICS INC. (F/K/A MENLO THERAPEUTICS INC. AND SUCCESSOR-IN-INTEREST TO VYNE PHARMACEUTICALS LTD., F/K/A FOAMIX PHARMACEUTICALS LTD.) | 2005-07-28 | — | — | US | disclosed |
| EP-1448788-A2 | PROCESS FOR THE SYNTHESIS OF (R)-1-(3,5-BIS(TRIFLUOROMETHYL)-PHENYL)ETHAN-1-OL AND ESTERS THEREOF BY DYNAMIC KINETIC RESOLUTION | Merck & Co., Inc. (US) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003043575-A2 | PROCESS FOR THE SYNTHESIS OF (R)-1-(3,5-BIS(TRIFLUOROMETHYL)-PHENYL)ETHAN-1-OL AND ESTERS THEREOF BY DYNAMIC KINETIC RESOLUTION | MERCK & CO., INC. (US) | 2003-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165083-A1 | Hydroisoindoline tachykinin receptor antagonists | TACR1, TACR2, NPSR1 | PDE2A 1870/4885CES2 3886/4885TACR1 1/4885 |
| US-20260085334-A1 | ENGINEERED KETOREDUCTASES FOR THE PREPARATION OF CHIRAL ALCOHOLS AND METHODS THEREOF | ADH1A, CYP4F11, ADH1C | PDE2A 2396/4885CES2 163/4885TACR1 3687/4885 |
| US-20130190540-A1 | METHOD FOR PREPARING OPTICALLY ACTIVE 1-BROMO-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANE | RPP30, BRPF1, ALK | PDE2A 4036/4885CES2 1977/4885TACR1 747/4885 |
| US-20130225814-A1 | OPTICALLY ACTIVE DIBENZYLAMINE DERIVATIVE, AND METHOD FOR PREPARING THEREOF | PCSK9, LDLR, PCSK7 | PDE2A 2142/4885CES2 3105/4885TACR1 1937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.