Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30557784 | 0.78 | ALDH1A1 (0.50) | GPR35ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL2178791 | 0.78 | ALDH1A1 (0.50) | GPR35ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL202907 | 0.77 | ERN1 (0.46) | HSP90AA1HSP90AB1GPR35ALDH1A1KDM4E | |
| SCHEMBL31215172 | 0.77 | GPR35 (0.57) | HSP90AA1HSP90AB1GPR35ALDH1A1KDM4E | |
| SCHEMBL30350882 | 0.77 | TDP1 (0.49) | GPR35ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL3991031 | 0.77 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1GPR35ALDH1A1KDM4E | |
| SCHEMBL3146522 | 0.77 | GPR35 (0.44) | HSP90AA1HSP90AB1GPR35ALDH1A1KDM4E | |
| SCHEMBL131620 | 0.77 | GPR35 (0.57) | HSP90AA1HSP90AB1GPR35ALDH1A1KDM4E | |
| SCHEMBL29001447 | 0.77 | TDP1 (0.49) | GPR35ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL845293 | 0.77 | TDP1 (0.41) | HSP90AA1HSP90AB1GPR35ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363705-B9 | COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2012-11-07 | — | — | EP | disclosed |
| EP-1363705-B1 | COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2012-06-13 | — | — | EP | disclosed |