Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | EBP | Q15125 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2628930 | 0.78 | LMNA (0.38) | LMNACYP1A2CYP2D6EBPSIGMAR1 | |
| SCHEMBL20338907 | 0.70 | KDM4E (0.43) | KDM4E | |
| SCHEMBL2628935 | 0.67 | HRH3 (0.40) | LMNACYP1A2CYP2D6EBPSIGMAR1 | |
| SCHEMBL9706125 | 0.62 | EBP (0.72) | CYP1A2CYP2D6EBPSIGMAR1HTT | |
| SCHEMBL16963979 | 0.61 | EBP (0.47) | CYP1A2CYP2D6EBPSIGMAR1HTT | |
| SCHEMBL11580118 | 0.60 | HTR7 (0.54) | LMNACYP1A2CYP2D6EBPSIGMAR1 | |
| SCHEMBL21770769 | 0.59 | EBP (0.53) | CYP1A2CYP2D6EBPSIGMAR1HTT | |
| SCHEMBL2629004 | 0.59 | HTR7 (0.41) | CYP1A2CYP2D6EBPSIGMAR1HTT | |
| SCHEMBL11560923 | 0.59 | SIGMAR1 (0.41) | LMNACYP1A2CYP2D6EBPSIGMAR1 | |
| SCHEMBL9706154 | 0.59 | DRD3 (0.67) | LMNACYP1A2CYP2D6EBPSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363705-B9 | COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2012-11-07 | — | — | EP | disclosed |
| EP-1363705-B1 | COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2012-06-13 | — | — | EP | disclosed |