Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.53 |
| ▸ | ACACB | O00763 | 2/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3924311 | 0.92 | APP (0.46) | APPACACBAOC3ALDH1A1MAPK1 | |
| SCHEMBL23572596 | 0.91 | APP (0.49) | APPACACBKCNH2ALDH1A1 | |
| SCHEMBL2685285 | 0.91 | APP (0.49) | APPACACBKCNH2ALDH1A1 | |
| SCHEMBL2683955 | 0.91 | KMT2A (0.47) | APPACACBALDH1A1TSHRMAPK1 | |
| SCHEMBL22122696 | 0.91 | KMT2A (0.47) | APPACACBALDH1A1TSHRMAPK1 | |
| SCHEMBL1818040 | 0.88 | FAAH (0.48) | APPACACBMAPK1MCHR1 | |
| SCHEMBL1819985 | 0.88 | MCHR1 (0.48) | APPACACBAOC3ALDH1A1TSHR | |
| SCHEMBL5194250 | 0.87 | CA12 (0.46) | APPACACBAOC3CA12CA1 | |
| SCHEMBL7053252 | 0.84 | IGF1R (0.45) | ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL7734103 | 0.83 | MAPT (0.46) | ALDH1A1MAPK1L3MBTL1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2652552-A1 | PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS | Transitions Optical, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| WO-2013032608-A1 | INDENO-FUSED RING COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2013-03-07 | — | — | WO | disclosed |
| WO-2012082299-A1 | PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS | TRANSITIONS OPTICAL, INC. (US) | 2012-06-21 | — | — | WO | disclosed |