Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.49 |
| ▸ | ACP3 | P15309 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.44 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23572596 | 1.00 | APP (0.49) | APPACP3KMT2ACACNA2D1CACNB2 | |
| SCHEMBL22122696 | 0.93 | KMT2A (0.47) | APPACP3KMT2ACACNA2D1CACNB2 | |
| SCHEMBL2683955 | 0.93 | KMT2A (0.47) | APPACP3KMT2ACACNA2D1CACNB2 | |
| SCHEMBL9942722 | 0.91 | APP (0.53) | APPACACBALDH1A1KCNH2 | |
| SCHEMBL13859211 | 0.85 | DHFR (0.45) | KMT2ACACNA2D1CACNB2CACNA1CMEN1 | |
| SCHEMBL3924311 | 0.84 | APP (0.46) | APPKMT2AMEN1NPC1RAB9A | |
| SCHEMBL2802710 | 0.83 | AOC3 (0.46) | DHFR | |
| SCHEMBL2468153 | 0.82 | DHFR (0.51) | KMT2AMEN1NPC1POLBRAB9A | |
| SCHEMBL2519799 | 0.82 | TSHR (0.52) | APPKMT2ACACNA2D1CACNB2CACNA1C | |
| SCHEMBL2801832 | 0.82 | TSHR (0.52) | APPKMT2ACACNA2D1CACNB2CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168835-B2 | Method for preparing propargylic alcohol catalyzed by 2-morpholinoisobornane-10-thiol | NATIONAL TSING HUA UNIVERSITY (TW) | 2012-05-01 | — | — | US | disclosed |
| US-20110295042-A1 | METHOD FOR PREPARING PROPARGYLIC ALCOHOL CATALYZED BY 2-MORPHOLINOISOBORNANE-10-THIOL | NATIONAL TSING HUA UNIVERSITY (TW) | 2011-12-01 | — | — | US | disclosed |
| EP-1872173-A1 | PHOTOCHROMIC MATERIALS HAVING EXTENDED PI-CONJUGATED SYSTEMS AND COMPOSITIONS AND ARTICLES INCLUDING THE SAME | TRANSITIONS OPTICAL, INC. (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-1869140-A1 | OPHTHALMIC DEVICES COMPRISING PHOTOCHROMIC MATERIALS HAVING EXTENDED PI-CONJUGATED SYSTEMS | Johnson and Johnson Vision Care, Inc. (US) | 2007-12-26 | — | — | EP | disclosed |
| EP-1866699-A1 | PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS | TRANSITIONS OPTICAL, INC. (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006110513-A1 | OPHTHALMIC DEVICES COMPRISING PHOTOCHROMIC MATERIALS HAVING EXTENDED PI-CONJUGATED SYSTEMS | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2006-10-19 | — | — | WO | disclosed |
| WO-2006110221-A1 | PHOTOCHROMIC MATERIALS HAVING EXTENDED PI-CONJUGATED SYSTEMS AND COMPOSITIONS AND ARTICLES INCLUDING THE SAME | TRANSITIONS OPTICAL, INC. (US) | 2006-10-19 | — | — | WO | disclosed |
| WO-2006110219-A1 | PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS | TRANSITIONS OPTICAL, INC. (US) | 2006-10-19 | — | — | WO | disclosed |
| EP-1248778-A1 | SUBSTITUTED PHOTOCHROMIC 2H-NAPHTHO 1,2-B] PYRAN COMPOUNDS | PPG Industries Ohio Inc. (US) | 2002-10-16 | — | — | EP | disclosed |
| WO-2001051483-A1 | SUBSTITUTED PHOTOCHROMIC 2H-NAPHTHO [1,2-B] PYRAN COMPOUNDS | PPG INDUSTRIES OHIO, INC. (US) | 2001-07-19 | — | — | WO | disclosed |
| EP-0560898-A4 | PHOTOCHROMIC NAPHTHOPYRANS | — | 1993-11-18 | — | — | EP | disclosed |
| EP-0560898-A1 | PHOTOCHROMIC NAPHTHOPYRANS. | PPG INDUSTRIES INC (US) | 1993-09-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110295042-A1 | METHOD FOR PREPARING PROPARGYLIC ALCOHOL CATALYZED BY 2-MORPHOLINOISOBORNANE-10-THIOL | GRHPR, ADH1C, ADH5 | APP 3945/4885ACP3 4748/4885KMT2A 682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.