Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9942857 | 0.85 | CFTR (0.71) | CFTRALDH1A1MAPTPTGS1KDM4E | |
| SCHEMBL2389504 | 0.84 | RORC (0.47) | CFTRALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL2389824 | 0.79 | CFTR (0.44) | CFTRALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL5165192 | 0.78 | CFTR (0.52) | CFTRALDH1A1MAPTKDM4EGAA | |
| SCHEMBL23541000 | 0.77 | SLC6A4 (0.49) | CFTRALDH1A1PTGS1KDM4ELMNA | |
| SCHEMBL29476278 | 0.77 | SLC6A4 (0.49) | CFTRALDH1A1PTGS1KDM4ELMNA | |
| SCHEMBL29580754 | 0.76 | CFTR (0.49) | CFTRALDH1A1MAPTPTGS1KDM4E | |
| SCHEMBL2796211 | 0.76 | CFTR (0.49) | CFTRALDH1A1MAPTPTGS1KDM4E | |
| SCHEMBL9942845 | 0.75 | CFTR (0.67) | CFTRALDH1A1MAPTKDM4EGAA | |
| SCHEMBL24524870 | 0.75 | ABL1 (0.44) | CFTRALDH1A1MAPTPIK3CAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2476671-A1 | 1H-Quinazoline-2,4-diones | Novartis AG (CH) | 2012-07-18 | — | — | EP | disclosed |
| EP-2468732-A1 | 1H-Quinazoline-2,4-diones | Novartis AG (CH) | 2012-06-27 | — | — | EP | disclosed |
| EP-2463278-A1 | 1H-QUINAZ0LINE-2,4-DIONES AND THEIR USE AS AMPA-RECEPTOR LIGANDS | Novartis AG (CH) | 2012-06-13 | — | — | EP | disclosed |