Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21777655 | 0.86 | KDM4E (0.58) | ABCG2NR4A2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL29476211 | 0.83 | ABCG2 (0.56) | ABCG2NR4A2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL3990612 | 0.83 | ABCG2 (0.56) | ABCG2NR4A2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL4585616 | 0.81 | ABCG2 (0.49) | ABCG2NR4A2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL4577829 | 0.81 | NR4A2 (0.56) | ABCG2NR4A2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL29773857 | 0.81 | NR4A2 (0.56) | ABCG2NR4A2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL14574822 | 0.80 | KDM4E (0.70) | ABCG2NR4A2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL3839211 | 0.79 | NR4A2 (0.54) | ABCG2NR4A2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL9942872 | 0.79 | ACLY (0.55) | ALDH1A1KDM4EPOLBHPGDMAPT | |
| SCHEMBL24373505 | 0.79 | KDM4E (0.54) | ABCG2ALDH1A1GAAL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2468732-B1 | 1H-Quinazoline-2,4-diones | NOVARTIS AG (CH) | 2014-08-20 | — | — | EP | disclosed |
| EP-2476671-A1 | 1H-Quinazoline-2,4-diones | Novartis AG (CH) | 2012-07-18 | — | — | EP | disclosed |
| EP-2468732-A1 | 1H-Quinazoline-2,4-diones | Novartis AG (CH) | 2012-06-27 | — | — | EP | disclosed |
| EP-2463278-A1 | 1H-QUINAZ0LINE-2,4-DIONES AND THEIR USE AS AMPA-RECEPTOR LIGANDS | Novartis AG (CH) | 2012-06-13 | — | — | EP | disclosed |