Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.32 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.30 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2387499 | 0.82 | IMPDH2 (0.32) | IMPDH2SOS1KDM5B | |
| SCHEMBL2392964 | 0.67 | PARG (0.37) | KDM5B | |
| SCHEMBL2392182 | 0.67 | SOS1 (0.33) | SOS1 | |
| SCHEMBL12798977 | 0.66 | CA12 (0.31) | — | |
| SCHEMBL2390366 | 0.65 | CA12 (0.36) | — | |
| Selurampanel SCHEMBL1660562 | 0.61 | HAVCR2 (0.34) | IMPDH2 | |
| SCHEMBL12798979 | 0.61 | USP1 (0.36) | — | |
| SCHEMBL1067354 | 0.61 | USP1 (0.36) | — | |
| SCHEMBL12180698 | 0.58 | ALDH1A1 (0.34) | KDM5B | |
| SCHEMBL17661898 | 0.54 | CYP17A1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2476671-A1 | 1H-Quinazoline-2,4-diones | Novartis AG (CH) | 2012-07-18 | — | — | EP | disclosed |
| EP-2468732-A1 | 1H-Quinazoline-2,4-diones | Novartis AG (CH) | 2012-06-27 | — | — | EP | disclosed |
| EP-2463278-A1 | 1H-QUINAZ0LINE-2,4-DIONES AND THEIR USE AS AMPA-RECEPTOR LIGANDS | Novartis AG (CH) | 2012-06-13 | — | — | EP | disclosed |