Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Dipyridyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | CCR1 | P32246 | 3/20 | 0.52 |
| ▸ | CCR5 | P51681 | 3/20 | 0.52 |
| ▸ | CCR8 | P51685 | 3/20 | 0.52 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | METAP1 | P53582 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dipyridyl SCHEMBL5456778 | 1.00 | KDM4E (0.52) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL7143241 | 0.94 | KDM4E (0.58) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL28370248 | 0.94 | KDM4E (0.58) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL5691657 | 0.93 | KDM4E (0.52) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL3491432 | 0.92 | KDM4E (0.56) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL3847534 | 0.92 | KDM4E (0.56) | KDM4ELMNACCR1CCR5CCR8 | |
| Imidazole SCHEMBL28227084 | 0.84 | CYP2A6 (0.50) | KDM4ELMNACCR1CCR5CCR8 | |
| 2-Chloropyridine SCHEMBL6446841 | 0.79 | TDP1 (0.61) | KDM4ELMNACCR1CCR5CCR8 | |
| Imidazole SCHEMBL28676934 | 0.78 | ALDH1A1 (0.41) | KDM4ELMNACCR1CCR5CCR8 | |
| Imidazole SCHEMBL27841951 | 0.78 | CYP2A6 (0.41) | KDM4ELMNACCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557989-B2 | Electrochemical affinity biosensor system and methods | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2013-10-15 | — | — | US | disclosed |
| EP-1646637-B1 | ELECTROCHEMICAL AFFINITY BIOSENSOR SYSTEM AND METHODS | ROCHE DIAGNOSTICS GMBH (DE) | 2012-08-15 | — | — | EP | disclosed |
| EP-2465862-A1 | Mononuclear osmium complexes for use in biosensors | Roche Diagniostics GmbH (DE) | 2012-06-20 | — | — | EP | disclosed |