Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1027806 | 0.90 | GRIK1 (0.50) | LMNASMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL443151 | 0.86 | HDAC3 (0.48) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL1574137 | 0.86 | HDAC3 (0.48) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4667862 | 0.86 | HDAC3 (0.48) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL553139 | 0.85 | LMNA (0.51) | LMNAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL553141 | 0.85 | LMNA (0.51) | LMNAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL445601 | 0.81 | TBXAS1 (0.50) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL813333 | 0.81 | TBXAS1 (0.50) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL9943873 | 0.81 | GRIK1 (0.49) | LMNAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL9943865 | 0.81 | KMT2A (0.49) | LMNAHDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2464368-A1 | CATHEPSIN C INHIBITORS | Glaxo Group Limited (GB) | 2012-06-20 | — | — | EP | claimed |
| EP-2464368-A1 | CATHEPSIN C INHIBITORS | Glaxo Group Limited (GB) | 2012-06-20 | — | — | EP | disclosed |