Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.51 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SNCA | P37840 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1458437 | 0.89 | MITF (0.57) | NPC1KDM4EALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL9944324 | 0.84 | GAA (0.50) | NPC1KDM4EALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL9944170 | 0.84 | KMT2A (0.64) | NPC1KDM4EALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL9944195 | 0.84 | MAPT (0.62) | NPC1KDM4EALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL1457728 | 0.81 | MEN1 (0.54) | NPC1KDM4EALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL9944181 | 0.80 | SMN1; SMN2 (0.62) | NPC1KDM4EALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL9944194 | 0.80 | KMT2A (0.56) | NPC1KDM4EALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL9944240 | 0.78 | MAPT (0.58) | NPC1KDM4EALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL9944219 | 0.78 | TAS1R3 (0.55) | NPC1KDM4EALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL5973851 | 0.77 | NPC1 (0.65) | NPC1KDM4ESMN1; SMN2RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149737-A1 | Therapeutic Aryl-Amido-Aryl Compounds and Their Use | KING'S COLLEGE LONDON (GB) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149737-A1 | Therapeutic Aryl-Amido-Aryl Compounds and Their Use | RARA, RARB, RARG | NPC1 277/4885KDM4E 2548/4885ALDH1A1 128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.