Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | PPARA | Q07869 | 9/20 | 0.55 |
| ▸ | PPARG | P37231 | 6/20 | 0.51 |
| ▸ | PPARD | Q03181 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylethyl Carbamate SCHEMBL111316 | 0.84 | LMNA (0.79) | LMNARAB9AL3MBTL1NPC1TDP1 | |
| SCHEMBL114506 | 0.83 | PLAU (0.50) | LMNAPPARAPPARGPPARDRAB9A | |
| SCHEMBL114505 | 0.83 | PLAU (0.50) | LMNAPPARAPPARGPPARDRAB9A | |
| SCHEMBL28163570 | 0.81 | LMNA (0.50) | LMNAPPARARAB9AL3MBTL1NPC1 | |
| SCHEMBL14856087 | 0.81 | LMNA (0.64) | LMNARAB9AL3MBTL1NPC1TDP1 | |
| SCHEMBL30733598 | 0.80 | LMNA (0.46) | LMNAPPARAPPARGPPARDRAB9A | |
| SCHEMBL14603427 | 0.79 | PPARA (0.50) | PPARAPPARGPPARDRAB9AL3MBTL1 | |
| SCHEMBL25447798 | 0.77 | PPARA (0.50) | LMNAPPARAPPARGPPARDSMN1; SMN2 | |
| Azobenzene SCHEMBL28244550 | 0.76 | ALOX15 (0.56) | LMNARAB9AL3MBTL1NPC1TDP1 | |
| Carbamic Acid Phenyl Ester SCHEMBL667176 | 0.76 | PPARA (0.46) | LMNAPPARAPPARGPPARDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4121072-A1 | CYCLIC SULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | Amathus Therapeutics, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |
| WO-2021188911-A1 | CYCLIC SULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |
| EP-3773683-A1 | AZIDE INSULIN ANALOGUES | Merck Sharp&Dohme Corp. (US) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019199628-A1 | AZIDE INSULIN ANALOGUES | MERCK SHARP & DOHME CORP. (US) | 2019-10-17 | — | — | WO | disclosed |
| EP-2453908-A2 | BIFUNCTIONAL STAPLED POLYPEPTIDES AND USES THEREOF | President and Fellows of Harvard College (US) | 2012-05-23 | — | — | EP | disclosed |
| EP-2331525-A2 | HALOFUGINONE ANALOGS FOR INHIBITION OF TRNA SYNTHETASES AND USES THEREOF | President and Fellows of Harvard College (US) | 2011-06-15 | — | — | EP | disclosed |
| WO-2011008260-A2 | BIFUNCTIONAL STAPLED POLYPEPTIDES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-01-20 | — | — | WO | disclosed |
| WO-2010019210-A2 | HALOFUGINONE ANALOGS FOR INHIBITION OF TRNA SYNTHETASES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-02-18 | — | — | WO | disclosed |