Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.51 |
| ▸ | CCND1 | P24385 | 1/20 | 0.51 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.44 |
| ▸ | SGMS2 | Q8NHU3 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15614303 | 0.86 | CDK4 (0.44) | CDK4CCND1NISCHCYP1A2L3MBTL1 | |
| SCHEMBL1539449 | 0.81 | NISCH (0.48) | NISCHMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL1539447 | 0.81 | NISCH (0.48) | NISCHMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL2288075 | 0.81 | ALDH1A1 (0.53) | NISCHMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL3521430 | 0.81 | CDK4 (0.60) | CDK4CCND1NISCHHTR1AADRA1D | |
| SCHEMBL15936149 | 0.80 | CDK4 (0.55) | CDK4CCND1HTR1AADRA1DADRA1A | |
| SCHEMBL3458725 | 0.80 | NISCH (0.47) | NISCHMEN1KMT2ACYP1A2CYP3A4 | |
| Bromide SCHEMBL27650271 | 0.80 | CDK4 (0.58) | CDK4CCND1NISCHHTR1AADRA1D | |
| SCHEMBL18312560 | 0.79 | L3MBTL1 (0.53) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1539493 | 0.78 | CDK4 (0.47) | CDK4CCND1NISCHMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | HTR2C, GRK2, GRK3 | CDK4 2582/4885CCND1 4722/4885NISCH 4799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.