Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3032322 | 0.89 | ALDH1A1 (0.53) | HTTALDH1A1LMNAGAANPSR1 | |
| SCHEMBL5209802 | 0.87 | ALDH1A1 (0.52) | HTTALDH1A1MAPTLMNANPSR1 | |
| SCHEMBL4059370 | 0.87 | ALDH1A1 (0.51) | HTTALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3036700 | 0.87 | HTT (0.56) | HTTALDH1A1POLBTSHRNPSR1 | |
| SCHEMBL3033421 | 0.86 | HTT (0.58) | HTTALDH1A1MAPTLMNAGAA | |
| SCHEMBL3032698 | 0.86 | ALDH1A1 (0.54) | HTTALDH1A1MAPTLMNAGAA | |
| SCHEMBL3038647 | 0.85 | ALDH1A1 (0.49) | HTTALDH1A1POLBMAPTLMNA | |
| SCHEMBL2822374 | 0.85 | HTT (0.55) | HTTALDH1A1TSHRMAPK1LMNA | |
| SCHEMBL1374393 | 0.85 | ALDH1A1 (0.53) | HTTALDH1A1CYP2C19POLBMAPK1 | |
| SCHEMBL3029014 | 0.84 | HTT (0.56) | HTTALDH1A1MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125830-B1 | NEW PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLO[3,4-D]PYRIDAZIN-7(6H)-ONE | ALMIRALL SA (ES) | 2011-01-26 | — | — | EP | claimed |
| EP-2125830-B1 | NEW PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLO[3,4-D]PYRIDAZIN-7(6H)-ONE | ALMIRALL SA (ES) | 2011-01-26 | — | — | EP | disclosed |
| EP-2125830-B1 | NEW PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLO[3,4-D]PYRIDAZIN-7(6H)-ONE | ALMIRALL SA (ES) | 2011-01-26 | — | — | EP | disclosed |
| EP-2125830-B1 | NEW PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLO[3,4-D]PYRIDAZIN-7(6H)-ONE | ALMIRALL SA (ES) | 2011-01-26 | — | — | EP | disclosed |
| US-20100137591-A1 | PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLO [3,4-D]PYRIDAZIN-7(6H)-ONE | ALMIRALL, S.A. (ES) | 2010-06-03 | — | — | US | disclosed |
| US-20100137591-A1 | PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLO [3,4-D]PYRIDAZIN-7(6H)-ONE | ALMIRALL, S.A. (ES) | 2010-06-03 | — | — | US | disclosed |
| US-20100137591-A1 | PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLO [3,4-D]PYRIDAZIN-7(6H)-ONE | ALMIRALL, S.A. (ES) | 2010-06-03 | — | — | US | disclosed |
| US-20100137591-A1 | PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLO [3,4-D]PYRIDAZIN-7(6H)-ONE | ALMIRALL, S.A. (ES) | 2010-06-03 | — | — | US | disclosed |
| EP-2125830-A1 | NEW PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLOÝ3,4-D¨PYRIDAZIN-7(6H)-ONE | Almirall, S.A. (ES) | 2009-12-02 | — | — | EP | disclosed |
| EP-2125830-A1 | NEW PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLOÝ3,4-D¨PYRIDAZIN-7(6H)-ONE | Almirall, S.A. (ES) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008107064-A1 | NEW PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLO[3,4-D]PYRIDAZIN-7(6H)-ONE | ALMIRALL S.A. (ES) | 2008-09-12 | — | — | WO | disclosed |
| WO-2008107064-A1 | NEW PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLO[3,4-D]PYRIDAZIN-7(6H)-ONE | ALMIRALL S.A. (ES) | 2008-09-12 | — | — | WO | disclosed |
| WO-2008107064-A1 | NEW PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLO[3,4-D]PYRIDAZIN-7(6H)-ONE | ALMIRALL S.A. (ES) | 2008-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137591-A1 | PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLO [3,4-D]PYRIDAZIN-7(6H)-ONE | HPD, CYP4F11, CYP4F8 | HTT 1920/4885ALDH1A1 215/4885CYP3A4 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.