Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12256025 | 0.78 | GLO1 (0.48) | KEAP1HTTALOX15GLO1KDM4E | |
| SCHEMBL9949116 | 0.77 | MEN1 (0.33) | KEAP1HTTALOX15GLO1PTK2 | |
| SCHEMBL25680865 | 0.74 | PTGS1 (0.38) | KEAP1PIK3CBHTTALOX15GLO1 | |
| SCHEMBL28493309 | 0.73 | PTGS1 (0.39) | KEAP1PIK3CBHTTALOX15GLO1 | |
| SCHEMBL18555412 | 0.73 | EDNRA (0.44) | KEAP1PIK3CBHTTALOX15GLO1 | |
| SCHEMBL28499045 | 0.73 | EDNRA (0.44) | KEAP1PIK3CBGLO1KDM4EPIK3CD | |
| SCHEMBL28268009 | 0.71 | HSP90AA1 (0.62) | PIK3CBHSP90AA1CYP1A2CYP3A4KDM4E | |
| SCHEMBL13977617 | 0.71 | KEAP1 (0.40) | KEAP1HTTALOX15GLO1KDM4E | |
| SCHEMBL24743836 | 0.70 | MAPK1 (0.40) | CYP17A1HTTALOX15GLO1KDM4E | |
| SCHEMBL5029231 | 0.70 | HSP90AA1 (0.42) | HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165334-A1 | Indole/Benzimidazole Compounds as mTOR Kinase Inhibitors | AMGEN INC. (US) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165334-A1 | Indole/Benzimidazole Compounds as mTOR Kinase Inhibitors | MTOR, PIKFYVE, RICTOR | KEAP1 1380/4885PIK3CB 7/4885HSP90AA1 1183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.