Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 2/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 7/20 | 0.44 |
| ▸ | DHODH | Q02127 | 3/20 | 0.42 |
| ▸ | CHUK | O15111 | 4/20 | 0.42 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.42 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30009492 | 0.86 | BCAT2 (0.49) | BCAT2BRD4IKBKBDHODHCHUK | |
| SCHEMBL18816701 | 0.83 | BCAT2 (0.53) | BCAT2BRD4IKBKBDHODHCHUK | |
| SCHEMBL18816714 | 0.81 | DHODH (0.46) | BCAT2BRD4IKBKBDHODHCDC7 | |
| SCHEMBL6887769 | 0.79 | BCAT2 (0.56) | BCAT2BRD4IKBKBDHODHCHUK | |
| SCHEMBL20233004 | 0.77 | KAT6A (0.56) | BCAT2BRD4IKBKBDHODHCHUK | |
| SCHEMBL3296992 | 0.76 | IKBKB (0.54) | BCAT2BRD4IKBKBCHUKIKBKE | |
| SCHEMBL6135786 | 0.75 | BCAT2 (0.41) | BCAT2BRD4IKBKBDHODHCHUK | |
| SCHEMBL4514123 | 0.74 | DGAT1 (0.41) | — | |
| SCHEMBL27708585 | 0.74 | BCAT2 (0.50) | BCAT2BRD4IKBKBDHODHCHUK | |
| SCHEMBL3837776 | 0.74 | DHODH (0.46) | BCAT2BRD4IKBKBDHODHCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015191677-A1 | BICYCLIC HETEROARYLAMINOALKYL PHENYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2015-12-17 | — | — | WO | disclosed |
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |