Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9954214 | 0.84 | PIK3CD (0.36) | PTGS2GPR55PIK3CGPIK3C3CYP11B2 | |
| SCHEMBL9953789 | 0.81 | PTGS2 (0.39) | PTGS2GPR55PIK3CGPIK3C3CYP11B2 | |
| SCHEMBL9952916 | 0.77 | PIK3CD (0.35) | PTGS2GPR55PIK3CGPIK3C3CYP11B2 | |
| SCHEMBL9952021 | 0.67 | PIK3CG (0.36) | PTGS2GPR55PIK3CGPIK3C3PIK3CD | |
| SCHEMBL5700076 | 0.66 | CA12 (0.44) | PTGS2PIK3C3CYP11B2 | |
| SCHEMBL9928787 | 0.65 | PIK3C3 (0.38) | PTGS2GPR55PIK3CGPIK3C3CYP11B2 | |
| SCHEMBL9929356 | 0.65 | PIK3CD (0.42) | PTGS2GPR55PIK3CGPIK3C3CYP11B2 | |
| Hydrochloric Acid SCHEMBL9928961 | 0.65 | PIK3CD (0.42) | PTGS2GPR55PIK3CGPIK3C3CYP11B2 | |
| SCHEMBL9952024 | 0.65 | PIK3CD (0.37) | PTGS2GPR55PIK3CGPIK3C3CYP11B2 | |
| Hydrochloric Acid SCHEMBL9953058 | 0.64 | PIK3CD (0.36) | PTGS2GPR55PIK3CGPIK3C3CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |