Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9954214 | 0.89 | PIK3CD (0.36) | PIK3CDPIK3C3CYP11B2CYP11B1GPR55 | |
| SCHEMBL9952018 | 0.77 | PTGS2 (0.36) | PIK3CDPIK3C3CYP11B2GPR55PIK3CG | |
| SCHEMBL9952919 | 0.68 | PIK3CD (0.41) | PIK3CDPIK3C3CYP11B2CYP11B1GPR55 | |
| SCHEMBL9929127 | 0.66 | PIK3CD (0.47) | PIK3CDPIK3C3CYP11B2GPR55PIK3CG | |
| SCHEMBL5700076 | 0.66 | CA12 (0.44) | PIK3C3CYP11B2CYP11B1PTGS2 | |
| SCHEMBL9952178 | 0.65 | PIK3CD (0.42) | PIK3CDPIK3C3CYP11B2CYP11B1PIK3CG | |
| Hydrochloric Acid SCHEMBL9929064 | 0.65 | PIK3CD (0.46) | PIK3CDPIK3C3GPR55PIK3CGPIK3CB | |
| SCHEMBL9954216 | 0.65 | PIK3CD (0.44) | PIK3CDPIK3C3CYP11B2CYP11B1GPR55 | |
| SCHEMBL17177772 | 0.64 | ALDH1A1 (0.38) | PIK3C3PTGS2MAPTKMT2A | |
| SCHEMBL19065431 | 0.64 | PIK3C3 (0.57) | PIK3CDPIK3C3GPR55PIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |