Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 6/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 3/20 | 0.35 |
| ▸ | INSR | P06213 | 3/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.35 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | KMO | O15229 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9928819 | 0.85 | PIK3CD (0.41) | MAP4K4AURKARPS6KB1PDPK1CHUK | |
| SCHEMBL9953815 | 0.85 | PIK3CD (0.35) | AURKARPS6KB1PDPK1KDM4EHTT | |
| SCHEMBL9960559 | 0.85 | ALDH1A1 (0.36) | KDM4EHTTSMN1; SMN2LMNAUSP2 | |
| SCHEMBL9952872 | 0.84 | KMO (0.38) | AURKARPS6KB1JAK2KMOLMNA | |
| SCHEMBL9953217 | 0.84 | PIK3CD (0.36) | KDM4EHTTLMNAUSP2ALDH1A1 | |
| SCHEMBL9953880 | 0.83 | PIK3CD (0.43) | JAK2KMOKDM4ESMN1; SMN2LMNA | |
| SCHEMBL9953808 | 0.77 | PIK3CD (0.38) | HTTSMN1; SMN2LMNAUSP2ALDH1A1 | |
| SCHEMBL9951999 | 0.76 | RPS6KB1 (0.33) | AURKARPS6KB1PDPK1HTTSMN1; SMN2 | |
| SCHEMBL9953054 | 0.76 | FGFR3 (0.40) | — | |
| SCHEMBL21986437 | 0.76 | LRRK2 (0.39) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | claimed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | claimed |
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |