Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952164 | 0.92 | PIK3CD (0.41) | RPS6KB1AURKAPDPK1AURKBPIK3CD | |
| SCHEMBL9953815 | 0.83 | PIK3CD (0.35) | RPS6KB1AURKAPDPK1PIK3CDMEN1 | |
| SCHEMBL9953808 | 0.82 | PIK3CD (0.38) | PIK3CDAXLMERTKMEN1LMNA | |
| SCHEMBL9954211 | 0.80 | LMNA (0.39) | MEN1LMNATSHRKMT2ASMN1; SMN2 | |
| SCHEMBL9928873 | 0.80 | PIK3CD (0.45) | RPS6KB1PDPK1PIK3CDAXLMERTK | |
| SCHEMBL9952993 | 0.79 | FFAR1 (0.36) | HSD17B10 | |
| SCHEMBL9953781 | 0.78 | PIK3CD (0.39) | PIK3CDAXLMERTK | |
| SCHEMBL2012486 | 0.76 | PIK3CD (0.46) | PIK3CDMEN1LMNATSHRHTT | |
| SCHEMBL9952025 | 0.76 | MAP4K4 (0.37) | RPS6KB1AURKAPDPK1AURKBLMNA | |
| SCHEMBL9960500 | 0.76 | PIK3CD (0.40) | PIK3CDAXLMERTKMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | claimed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | claimed |
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |